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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5285
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 5
Synonyms ASK-1 | ASK1 | Apoptosis signal-regulating kinase 1 | MAP3K5 | MAPK/ERK kinase kinase 5 | MAPKKK5 | MEK kinase 5 | MEKK 5 | MEKK5 | Mitogen-activated protein kinase kinase kinase 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 5 SINGLE PROTEIN Q99683

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545429 GS-4997 Mitogen-activated protein kinase kinase kinase 5 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197442
Ensembl ENSG00000197442
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:1902911 (protein kinase complex)
GO:1990604 (IRE1-TRAF2-ASK1 complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002376 (immune system process)
GO:0002931 (response to ischemia)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007254 (JNK cascade)
GO:0007257 (activation of JUN kinase activity)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0010941 (regulation of cell death)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0038066 (p38MAPK cascade)
GO:0043065 (positive regulation of apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045087 (innate immune response)
GO:0045663 (positive regulation of myoblast differentiation)
GO:0046330 (positive regulation of JNK cascade)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0097190 (apoptotic signaling pathway)
GO:0097300 (programmed necrotic cell death)
GO:1901216 (positive regulation of neuron death)
GO:1902170 (cellular response to reactive nitrogen species)
Wikipedia ASK1

Target Cross References - Protein

canSAR Q99683
Human Protein Atlas ENSG00000197442
IntAct Q99683
Guide to Pharmacology 2080
Open Targets ENSG00000197442
PharmGKB PA30601
Pharos Q99683 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
UniProt A6NIA0 B4DGB2 Q5THN3 Q99461 Q99683

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013761 (SAM/pointed.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR025136 (DUF4071.)
Pfam PF00069 (Pkinase)
PF13281 (DUF4071)

Target Cross References - Structure

PDBe 2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
CREDO 2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
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