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Target Report Card

Target Name and Classification

Target ID CHEMBL5284
Target Type SINGLE PROTEIN
Preferred Name CaM-kinase kinase beta
Synonyms CAMKK2 | CAMKKB | CaM-KK 2 | CaM-KK beta | CaM-kinase kinase 2 | CaM-kinase kinase beta | CaMKK 2 | CaMKK beta | Calcium/calmodulin-dependent protein kinase kinase 2 | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase camkk family > other protein kinase meta subfamily

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase kinase 2 SINGLE PROTEIN Q96RR4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110931
Ensembl ENSG00000110931
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005509 (calcium ion binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019722 (calcium-mediated signaling)
GO:0045859 (regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046777 (protein autophosphorylation)
Wikipedia CAMKK2

Target Cross References - Protein

Human Protein Atlas ENSG00000110931
IntAct Q96RR4
Guide to Pharmacology 1957
Open Targets ENSG00000110931
PharmGKB PA26052
Pharos Q96RR4 (Tchem)
UniProt A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1 Q96RP2 Q96RR3 Q96RR4 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2ZV2
CREDO 2ZV2
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