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Target Report Card

Target Name and Classification

Target ID CHEMBL5282
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2A6
Synonyms 1,4-cineole 2-exo-monooxygenase | CYP2A3 | CYP2A6 | CYPIIA6 | Coumarin 7-hydroxylase | Cytochrome P450 2A6 | Cytochrome P450 IIA3 | Cytochrome P450(I)
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2a > cytochrome p450 2a6

Target Components

Component Description Relationship Accession
Cytochrome P450 2A6 SINGLE PROTEIN P11509

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000255974
Ensembl ENSG00000255974
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005881 (cytoplasmic microtubule)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008389 (coumarin 7-hydroxylase activity)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0008202 (steroid metabolic process)
GO:0009804 (coumarin metabolic process)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0042738 (exogenous drug catabolic process)
GO:0046226 (coumarin catabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2A6

Target Cross References - Protein

CGD CYP2A6-related drug metabolism
Human Protein Atlas ENSG00000255974
Guide to Pharmacology 1321
Open Targets ENSG00000255974
PharmGKB PA121
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
UniProt A7YAE5 B2R7F6 P00190 P10890 P11509 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008067 (Cyt_P450_E_grp-I_CYP2A-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
CREDO 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
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