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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5282
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2A6
Synonyms 1,4-cineole 2-exo-monooxygenase | CYP2A3 | CYP2A6 | CYPIIA6 | Coumarin 7-hydroxylase | Cytochrome P450 2A6 | Cytochrome P450 IIA3 | Cytochrome P450(I)
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2a > cytochrome p450 2a6

Target Components

Component Description Relationship Accession
Cytochrome P450 2A6 SINGLE PROTEIN P11509

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198077
Ensembl ENSG00000198077
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO Molecular Function GO:0008389 (coumarin 7-hydroxylase activity)
GO:0009055 (electron carrier activity)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0046226 (coumarin catabolic process)
Wikipedia CYP2A6

Target Cross References - Protein

CGD CYP2A6-related drug metabolism
Human Protein Atlas ENSG00000198077
Guide to Pharmacology 1321 (CYP2A6)
PharmGKB PA121
Reactome REACT_13433 (Biological oxidations.)
UniProt A7YAE5 B2R7F6 P00190 P10890 P11509 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008067 (Cyt_P450_E_grp-I_CYP2A-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS
CREDO 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS
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