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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5281
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2E1
Synonyms 4-nitrophenol 2-hydroxylase | CYP2E | CYP2E1 | CYPIIE1 | Cytochrome P450 2E1 | Cytochrome P450 2E1, N-terminally processed | Cytochrome P450-J
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2e > cytochrome p450 2e1

Target Components

Component Description Relationship Accession
Cytochrome P450 2E1 SINGLE PROTEIN P05181

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130649
Ensembl ENSG00000130649
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO Molecular Function GO:0009055 (electron carrier activity)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0046483 (heterocycle metabolic process)
Wikipedia CYP2E1

Target Cross References - Protein

canSAR P05181
Human Protein Atlas ENSG00000130649
Guide to Pharmacology 1330 (CYP2E1)
PharmGKB PA129
Reactome REACT_13433 (Biological oxidations.)
UniProt P05181 Q5VZD5 Q9UK47

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008070 (Cyt_P450_E_grp-I_CYP2E-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3E4E 3E6I 3GPH 3KOH 3LC4
CREDO 3E4E 3E6I 3GPH 3KOH 3LC4
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