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Target Report Card

Target Name and Classification

Target ID CHEMBL5281
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2E1
Synonyms 4-nitrophenol 2-hydroxylase | CYP2E | CYP2E1 | CYPIIE1 | Cytochrome P450 2E1 | Cytochrome P450 2E1, N-terminally processed | Cytochrome P450-J
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2e > cytochrome p450 2e1

Target Components

Component Description Relationship Accession
Cytochrome P450 2E1 SINGLE PROTEIN P05181

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130649
Ensembl ENSG00000130649
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0031227 (intrinsic component of endoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006641 (triglyceride metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0010193 (response to ozone)
GO:0010243 (response to organonitrogen compound)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0018885 (carbon tetrachloride metabolic process)
GO:0018910 (benzene metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0042197 (halogenated hydrocarbon metabolic process)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0046483 (heterocycle metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2E1

Target Cross References - Protein

canSAR P05181
Human Protein Atlas ENSG00000130649
IntAct P05181
Guide to Pharmacology 1330
Open Targets ENSG00000130649
PharmGKB PA129
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
UniProt P05181 Q5VZD5 Q6NWT9 Q9UK47

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008070 (Cyt_P450_E_grp-I_CYP2E-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
CREDO 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
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