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Target Report Card

Target Name and Classification

Target ID CHEMBL5275
Preferred Name Bone morphogenetic protein receptor type-1A
Synonyms ACVRLK3 | ALK-3 | ALK3 | Activin receptor-like kinase 3 | BMP type-1A receptor | BMPR-1A | BMPR1A | Bone morphogenetic protein receptor type-1A | CD_antigen=CD292 | SKR5 | Serine/threonine-protein kinase receptor R5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
Bone morphogenetic protein receptor type-1A SINGLE PROTEIN P36894

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107779
Ensembl ENSG00000107779
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:1990712 (HFE-transferrin receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0098821 (BMP receptor activity)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0001707 (mesoderm formation)
GO:0001756 (somitogenesis)
GO:0001880 (Mullerian duct regression)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002062 (chondrocyte differentiation)
GO:0003007 (heart morphogenesis)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003151 (outflow tract morphogenesis)
GO:0003161 (cardiac conduction system development)
GO:0003183 (mitral valve morphogenesis)
GO:0003186 (tricuspid valve morphogenesis)
GO:0003203 (endocardial cushion morphogenesis)
GO:0003215 (cardiac right ventricle morphogenesis)
GO:0003222 (ventricular trabecula myocardium morphogenesis)
GO:0003223 (ventricular compact myocardium morphogenesis)
GO:0003272 (endocardial cushion formation)
GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007389 (pattern specification process)
GO:0007398 (ectoderm development)
GO:0007399 (nervous system development)
GO:0007492 (endoderm development)
GO:0007507 (heart development)
GO:0009950 (dorsal/ventral axis specification)
GO:0009952 (anterior/posterior pattern specification)
GO:0009953 (dorsal/ventral pattern formation)
GO:0010665 (regulation of cardiac muscle cell apoptotic process)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0014032 (neural crest cell development)
GO:0014912 (negative regulation of smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0019827 (stem cell population maintenance)
GO:0021983 (pituitary gland development)
GO:0021998 (neural plate mediolateral regionalization)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0035137 (hindlimb morphogenesis)
GO:0035912 (dorsal aorta morphogenesis)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042733 (embryonic digit morphogenesis)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048339 (paraxial mesoderm development)
GO:0048352 (paraxial mesoderm structural organization)
GO:0048368 (lateral mesoderm development)
GO:0048378 (regulation of lateral mesodermal cell fate specification)
GO:0048382 (mesendoderm development)
GO:0048568 (embryonic organ development)
GO:0048589 (developmental growth)
GO:0048598 (embryonic morphogenesis)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050768 (negative regulation of neurogenesis)
GO:0051216 (cartilage development)
GO:0060021 (palate development)
GO:0060043 (regulation of cardiac muscle cell proliferation)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0060896 (neural plate pattern specification)
GO:0060914 (heart formation)
GO:0061312 (BMP signaling pathway involved in heart development)
GO:0061626 (pharyngeal arch artery morphogenesis)
GO:0071773 (cellular response to BMP stimulus)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1904414 (positive regulation of cardiac ventricle development)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:1905285 (fibrous ring of heart morphogenesis)
GO:1905292 (regulation of neural crest cell differentiation)
GO:2000772 (regulation of cellular senescence)
Wikipedia BMPR1A

Target Cross References - Protein

canSAR P36894
CGD Polyposis syndrome, hereditary mixed, 2; Polyposis, juvenile intestinal
Human Protein Atlas ENSG00000107779
IntAct P36894
Guide to Pharmacology 1786
Open Targets ENSG00000107779
PharmGKB PA25386
Pharos P36894 (Tchem)
Reactome R-HSA-201451 (Signaling by BMP.)
UniProt A8K6U9 P36894 Q8NEN8

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF01064 (Activin_recp)
PF07714 (Pkinase_Tyr)
PF08515 (TGF_beta_GS)

Target Cross References - Structure

PDBe 1ES7 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3NH7 3QB4
CREDO 1ES7 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3NH7 3QB4