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Target Report Card

Target Name and Classification

Target ID CHEMBL5272
Preferred Name Glycogen debranching enzyme
Synonyms 4-alpha-glucanotransferase | AGL | Amylo-1,6-glucosidase | Amylo-alpha-1,6-glucosidase | Dextrin 6-alpha-D-glucosidase | GDE | Glycogen debrancher | Glycogen debranching enzyme | Oligo-1,4-1,4-glucantransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glycogen debranching enzyme SINGLE PROTEIN P35573

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162688
Ensembl ENSG00000162688
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016234 (inclusion body)
GO:0016529 (sarcoplasmic reticulum)
GO:0043033 (isoamylase complex)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004133 (glycogen debranching enzyme activity)
GO:0004134 (4-alpha-glucanotransferase activity)
GO:0004135 (amylo-alpha-1,6-glucosidase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0030246 (carbohydrate binding)
GO:0030247 (polysaccharide binding)
GO:0031593 (polyubiquitin binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0005980 (glycogen catabolic process)
GO:0007584 (response to nutrient)
GO:0008152 (metabolic process)
GO:0009725 (response to hormone)
GO:0051384 (response to glucocorticoid)
Wikipedia Glycogen_debranching_enzyme

Target Cross References - Protein

canSAR P35573
CGD Glycogen storage disease III
Human Protein Atlas ENSG00000162688
IntAct P35573
Open Targets ENSG00000162688
PharmGKB PA24618
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-70221 (Glycogen breakdown (glycogenolysis).)
UniProt A6NCX7 A6NEK2 D3DT51 P35573 P78354 P78544 Q59H92 Q6AZ90 Q9UF08

Target Cross References - Domain

InterPro IPR006421 (Glycogen_debranch_met.)
IPR008928 (6-hairpin_glycosidase-like.)
IPR010401 (AGL/Gdb1.)
IPR013781 (Glyco_hydro_catalytic_dom.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR029436 (AGL_euk_N.)
IPR032788 (AGL_central.)
IPR032790 (GDE_C.)
IPR032792 (AGL_glucanoTrfase.)
Pfam PF06202 (GDE_C)
PF14699 (hGDE_N)
PF14701 (hDGE_amylase)
PF14702 (hGDE_central)