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Target Report Card

Target Name and Classification

Target ID CHEMBL5255
Preferred Name Toll-like receptor 4
Synonyms CD_antigen=CD284 | TLR4 | Toll-like receptor 4 | hToll
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Toll-like receptor 4 SINGLE PROTEIN O00206

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038512 Toll-like receptor 4/MD-2 PROTEIN COMPLEX
CHEMBL3038513 Toll-like receptor 4/MD-2/CD14 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136869
Ensembl ENSG00000136869
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0046696 (lipopolysaccharide receptor complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001875 (lipopolysaccharide receptor activity)
GO:0004888 (transmembrane receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0007252 (I-kappaB phosphorylation)
GO:0008063 (Toll signaling pathway)
GO:0010572 (positive regulation of platelet activation)
GO:0016046 (detection of fungus)
GO:0032497 (detection of lipopolysaccharide)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032700 (negative regulation of interleukin-17 production)
GO:0032707 (negative regulation of interleukin-23 production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032722 (positive regulation of chemokine production)
GO:0032727 (positive regulation of interferon-alpha production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032732 (positive regulation of interleukin-1 production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0042088 (T-helper 1 type immune response)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0045084 (positive regulation of interleukin-12 biosynthetic process)
GO:0045087 (innate immune response)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0060729 (intestinal epithelial structure maintenance)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia TLR_4

Target Cross References - Protein

canSAR O00206
Human Protein Atlas ENSG00000136869
IntAct O00206
Guide to Pharmacology 1754 (TLR4)
PharmGKB PA36552
Reactome REACT_6900 (Signaling in Immune system.)
UniProt A8K1Y8 A9XLP9 A9XLQ0 A9XLQ1 B4E194 O00206 Q5VZI8 Q5VZI9 Q9UK78 Q9UM57

Target Cross References - Domain

InterPro IPR000157 (Toll-Interleukin_rcpt.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR017241 (Toll-like_receptor.)
Pfam PF00560 (LRR_1)
PF01582 (TIR)

Target Cross References - Structure

PDBe 2Z62 2Z63 2Z65 2Z66 3FXI
CREDO 2Z62 2Z63 2Z65 2Z66 3FXI