ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5216
Target Type SINGLE PROTEIN
Preferred Name Uridine 5'-monophosphate synthase
Synonyms ODC | OMPdecase | OPRT | OPRTase | Orotate phosphoribosyltransferase | Orotidine 5'-phosphate decarboxylase | UMP synthase | UMPS | Uridine 5'-monophosphate synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Uridine 5'-monophosphate synthase SINGLE PROTEIN P11172

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114491
Ensembl ENSG00000114491
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004588 (orotate phosphoribosyltransferase activity)
GO:0004590 (orotidine-5'-phosphate decarboxylase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0016829 (lyase activity)
GO:0016831 (carboxy-lyase activity)
GO Biological Process GO:0006207 (de novo pyrimidine nucleobase biosynthetic process)
GO:0006221 (pyrimidine nucleotide biosynthetic process)
GO:0006222 (UMP biosynthetic process)
GO:0007565 (female pregnancy)
GO:0007595 (lactation)
GO:0008152 (metabolic process)
GO:0009116 (nucleoside metabolic process)
GO:0035690 (cellular response to drug)
GO:0044205 (de novo UMP biosynthetic process)
GO:0046134 (pyrimidine nucleoside biosynthetic process)
Wikipedia Uridine_monophosphate_synthetase

Target Cross References - Protein

canSAR P11172
CGD Orotic aciduria
Human Protein Atlas ENSG00000114491
IntAct P11172
Open Targets ENSG00000114491
PharmGKB PA363
Reactome R-HSA-500753 (Pyrimidine biosynthesis.)
UniProt B5LY68 B5LY72 O00758 O00759 O00760 P11172 Q16862 Q9H3Q2 Q9UG49

Target Cross References - Domain

InterPro IPR000836 (PRibTrfase_dom.)
IPR001754 (OMPdeCOase_dom.)
IPR004467 (Or_phspho_trans_dom.)
IPR011060 (RibuloseP-bd_barrel.)
IPR013785 (Aldolase_TIM.)
IPR014732 (OMPdecase.)
IPR018089 (OMPdecase_AS.)
IPR023031 (OPRT.)
IPR029057 (PRTase-like.)
Pfam PF00156 (Pribosyltran)
PF00215 (OMPdecase)

Target Cross References - Structure

PDBe 2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ More...
CREDO 2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ More...
spacer
spacer