ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5198
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase 15
Synonyms ERK-7 | ERK-8 | ERK7 | ERK8 | Extracellular signal-regulated kinase 7 | Extracellular signal-regulated kinase 8 | MAP kinase 15 | MAPK 15 | MAPK15 | Mitogen-activated protein kinase 15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 15 SINGLE PROTEIN Q8TD08

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181085 ENSG00000274205
Ensembl ENSG00000181085 ENSG00000274205
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017124 (SH3 domain binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0008156 (negative regulation of DNA replication)
GO:0016310 (phosphorylation)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032355 (response to estradiol)
GO:0045732 (positive regulation of protein catabolic process)
GO:0046777 (protein autophosphorylation)
GO:0051973 (positive regulation of telomerase activity)
GO:1904355 (positive regulation of telomere capping)
Wikipedia MAPK15

Target Cross References - Protein

canSAR Q8TD08
Human Protein Atlas ENSG00000181085 ENSG00000274205
IntAct Q8TD08
Guide to Pharmacology 2090
Open Targets ENSG00000181085 ENSG00000274205
PharmGKB PA142671478
Pharos Q8TD08 (Tchem)
UniProt Q2TCF9 Q8N362 Q8TD08

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
spacer
spacer