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Target Report Card

Target Name and Classification

Target ID CHEMBL5196
Target Type SINGLE PROTEIN
Preferred Name Fatty acid transport protein 5
Synonyms ACSB | ACSVL6 | BA-CoA ligase | BACS | BAL | Bile acid-CoA ligase | Bile acyl-CoA synthetase | Cholate--CoA ligase | FACVL3 | FATP-5 | FATP5 | Fatty acid transport protein 5 | Fatty-acid-coenzyme A ligase, very long-chain 3 | SLC27A5 | Solute carrier family 27 member 5 | VLACS-related | VLACSR | VLCS-H2 | VLCSH2 | Very long-chain acyl-CoA synthetase homolog 2 | Very long-chain acyl-CoA synthetase-related protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc27 family of fatty acid transporters

Target Components

Component Description Relationship Accession
Bile acyl-CoA synthetase SINGLE PROTEIN Q9Y2P5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000083807
Ensembl ENSG00000083807
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0009925 (basal plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004467 (long-chain fatty acid-CoA ligase activity)
GO:0005524 (ATP binding)
GO:0015245 (fatty acid transporter activity)
GO:0016874 (ligase activity)
GO:0031957 (very long-chain fatty acid-CoA ligase activity)
GO:0032403 (protein complex binding)
GO:0047747 (cholate-CoA ligase activity)
GO Biological Process GO:0000038 (very long-chain fatty acid metabolic process)
GO:0001676 (long-chain fatty acid metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006642 (triglyceride mobilization)
GO:0006699 (bile acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0008206 (bile acid metabolic process)
GO:0015721 (bile acid and bile salt transport)
GO:0015908 (fatty acid transport)
GO:0015911 (plasma membrane long-chain fatty acid transport)
GO:0046951 (ketone body biosynthetic process)
Wikipedia SLC27A5

Target Cross References - Protein

canSAR Q9Y2P5
Human Protein Atlas ENSG00000083807
IntAct Q9Y2P5
Open Targets ENSG00000083807
PharmGKB PA35873
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
UniProt B3KVP6 B4DPQ1 Q9Y2P5

Target Cross References - Domain

InterPro IPR000873 (AMP-dep_Synth/Lig.)
IPR020845 (AMP-binding_CS.)
IPR025110 (AMP-bd_C.)
IPR030302 (FATP5.)
Pfam PF00501 (AMP-binding)
PF13193 (AMP-binding_C)
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