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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5191
Target Type SINGLE PROTEIN
Preferred Name T-cell-specific surface glycoprotein CD28
Synonyms CD28 | CD_antigen=CD28 | T-cell-specific surface glycoprotein CD28 | TP44
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
T-cell-specific surface glycoprotein CD28 SINGLE PROTEIN P10747

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178562
Ensembl ENSG00000178562
GO Cellular Component GO:0005829 (cytosol)
GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO Molecular Function GO:0002020 (protease binding)
GO:0005070 (SH3/SH2 adaptor activity)
GO:0015026 (coreceptor activity)
GO Biological Process GO:0006959 (humoral immune response)
GO:0007166 (cell surface receptor linked signaling pathway)
GO:0016032 (viral reproduction)
GO:0031295 (T cell costimulation)
GO:0042089 (cytokine biosynthetic process)
GO:0045066 (regulatory T cell differentiation)
GO:0045070 (positive regulation of viral genome replication)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045727 (positive regulation of translation)
GO:0045768 (positive regulation of anti-apoptosis)
GO:0045840 (positive regulation of mitosis)
GO:0050690 (regulation of defense response to virus by virus)
Wikipedia CD28

Target Cross References - Protein

canSAR P10747
Human Protein Atlas ENSG00000178562
PharmGKB PA26207
Reactome REACT_6185 (HIV Infection.)
REACT_6900 (Signaling in Immune system.)
TIMBAL CD80%20(B7-1)
UniProt A8KAC1 P10747 Q13964 Q52M23 Q8NI54 Q8NI55 Q8NI56 Q8WXJ2 Q9BYV0

Target Cross References - Domain

InterPro IPR008093 (CD28.)
IPR013106 (Ig_V-set.)
IPR013783 (Ig-like_fold.)
Pfam PF07686 (V-set)

Target Cross References - Structure

PDBe 1YJD
CREDO 1YJD
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