ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5191
Preferred Name T-cell-specific surface glycoprotein CD28
Synonyms CD28 | CD_antigen=CD28 | T-cell-specific surface glycoprotein CD28 | TP44
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
T-cell-specific surface glycoprotein CD28 SINGLE PROTEIN P10747

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3137354 LULIZUMAB PEGOL T-cell-specific surface glycoprotein CD28 antagonist 2 PubMed
CHEMBL2109250 TGN-1412 T-cell-specific surface glycoprotein CD28 agonist 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178562
Ensembl ENSG00000178562
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0098636 (protein complex involved in cell adhesion)
GO Molecular Function GO:0002020 (protease binding)
GO:0005070 (SH3/SH2 adaptor activity)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0002863 (positive regulation of inflammatory response to antigenic stimulus)
GO:0006955 (immune response)
GO:0006959 (humoral immune response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0031295 (T cell costimulation)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0042089 (cytokine biosynthetic process)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0043066 (negative regulation of apoptotic process)
GO:0045060 (negative thymic T cell selection)
GO:0045066 (regulatory T cell differentiation)
GO:0045070 (positive regulation of viral genome replication)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045589 (regulation of regulatory T cell differentiation)
GO:0045727 (positive regulation of translation)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048304 (positive regulation of isotype switching to IgG isotypes)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050852 (T cell receptor signaling pathway)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0097190 (apoptotic signaling pathway)
Wikipedia CD28

Target Cross References - Protein

canSAR P10747
Human Protein Atlas ENSG00000178562
IntAct P10747
Guide to Pharmacology 2863
Open Targets ENSG00000178562
PharmGKB PA26207
Reactome R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-164939 (Nef mediated downregulation of CD28 cell surface expression.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
TIMBAL CD80%20(B7-1)
UniProt A8KAC1 P10747 Q13964 Q52M23 Q70WG0 Q8NI54 Q8NI55 Q8NI56 Q8WXJ2 Q9BYV0

Target Cross References - Domain

InterPro IPR008093 (CD28.)
IPR013106 (Ig_V-set.)
IPR013783 (Ig-like_fold.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF15910 (V-set_2)

Target Cross References - Structure