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Target Report Card

Target Name and Classification

Target ID CHEMBL5178
Target Type SINGLE PROTEIN
Preferred Name Nucleophosmin
Synonyms NPM | NPM | NPM1 | Nucleolar phosphoprotein B23 | Nucleolar protein NO38 | Nucleophosmin | Numatrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
Nucleophosmin SINGLE PROTEIN P06748

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111387 NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181163
Ensembl ENSG00000181163
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0031616 (spindle pole centrosome)
GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003713 (transcription coactivator activity)
GO:0003723 (RNA binding)
GO:0004860 (protein kinase inhibitor activity)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO:0030957 (Tat protein binding)
GO:0042393 (histone binding)
GO:0042803 (protein homodimerization activity)
GO:0043023 (ribosomal large subunit binding)
GO:0043024 (ribosomal small subunit binding)
GO:0044822 (poly(A) RNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0051059 (NF-kappaB binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0006281 (DNA repair)
GO:0006334 (nucleosome assembly)
GO:0006886 (intracellular protein transport)
GO:0006913 (nucleocytoplasmic transport)
GO:0006950 (response to stress)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007098 (centrosome cycle)
GO:0007165 (signal transduction)
GO:0007569 (cell aging)
GO:0008104 (protein localization)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010826 (negative regulation of centrosome duplication)
GO:0016032 (viral process)
GO:0032071 (regulation of endodeoxyribonuclease activity)
GO:0034080 (CENP-A containing nucleosome assembly)
GO:0042255 (ribosome assembly)
GO:0043066 (negative regulation of apoptotic process)
GO:0044387 (negative regulation of protein kinase activity by regulation of protein phosphorylation)
GO:0045727 (positive regulation of translation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046599 (regulation of centriole replication)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0060699 (regulation of endoribonuclease activity)
GO:0060735 (regulation of eIF2 alpha phosphorylation by dsRNA)
GO:1902751 (positive regulation of cell cycle G2/M phase transition)
Wikipedia NPM1

Target Cross References - Protein

canSAR P06748
Human Protein Atlas ENSG00000181163
IntAct P06748
Open Targets ENSG00000181163
PharmGKB PA31712
Reactome R-HSA-180746 (Nuclear import of Rev protein.)
R-HSA-606279 (Deposition of new CENPA-containing nucleosomes at the centromere.)
R-HSA-6804115 (TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.)
R-HSA-8869496 (TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.)
UniProt A8K3N7 B5BU00 D3DQL6 P06748 P08693 Q12826 Q13440 Q13441 Q14115 Q5EU94 Q5EU95 Q5EU96 Q5EU97 Q5EU98 Q5EU99 Q6V962 Q8WTW5 Q96AT6 Q96DC4 Q96EA5 Q9BYG9 Q9UDJ7

Target Cross References - Domain

InterPro IPR004301 (Nucleoplasmin.)
IPR024057 (Nucleoplasmin_core_dom.)
IPR032569 (NPM1_C.)
Pfam PF03066 (Nucleoplasmin)
PF16276 (NPM1-C)

Target Cross References - Structure

PDBe 2P1B 5EHD
CREDO 2P1B 5EHD
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