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Target Report Card

Target Name and Classification

Target ID CHEMBL5174
Preferred Name Neuropilin-1
Synonyms CD_antigen=CD304 | NRP | NRP1 | Neuropilin-1 | VEGF165R | Vascular endothelial cell growth factor 165 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor
  • secreted protein

Target Components

Component Description Relationship Accession
Neuropilin-1 SINGLE PROTEIN O14786

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099250
Ensembl ENSG00000099250
GO Cellular Component GO:0002116 (semaphorin receptor complex)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0005829 (cytosol)
GO:0005883 (neurofilament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030426 (growth cone)
GO:0031410 (cytoplasmic vesicle)
GO:0043025 (neuronal cell body)
GO:0043235 (receptor complex)
GO:0097443 (sorting endosome)
GO Molecular Function GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0015026 (coreceptor activity)
GO:0017154 (semaphorin receptor activity)
GO:0019838 (growth factor binding)
GO:0019955 (cytokine binding)
GO:0038085 (vascular endothelial growth factor binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001569 (patterning of blood vessels)
GO:0001764 (neuron migration)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002040 (sprouting angiogenesis)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0007413 (axonal fasciculation)
GO:0007507 (heart development)
GO:0008045 (motor neuron axon guidance)
GO:0009611 (response to wounding)
GO:0009887 (organ morphogenesis)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016358 (dendrite development)
GO:0016477 (cell migration)
GO:0021612 (facial nerve structural organization)
GO:0021636 (trigeminal nerve morphogenesis)
GO:0021637 (trigeminal nerve structural organization)
GO:0021649 (vestibulocochlear nerve structural organization)
GO:0021675 (nerve development)
GO:0021785 (branchiomotor neuron axon guidance)
GO:0021828 (gonadotrophin-releasing hormone neuronal migration to the hypothalamus)
GO:0030154 (cell differentiation)
GO:0030517 (negative regulation of axon extension)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0035767 (endothelial cell chemotaxis)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036486 (ventral trunk neural crest cell migration)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0038190 (VEGF-activated neuropilin signaling pathway)
GO:0043049 (otic placode formation)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0048485 (sympathetic nervous system development)
GO:0048666 (neuron development)
GO:0048841 (regulation of axon extension involved in axon guidance)
GO:0048842 (positive regulation of axon extension involved in axon guidance)
GO:0048843 (negative regulation of axon extension involved in axon guidance)
GO:0048844 (artery morphogenesis)
GO:0048846 (axon extension involved in axon guidance)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050918 (positive chemotaxis)
GO:0060301 (positive regulation of cytokine activity)
GO:0060385 (axonogenesis involved in innervation)
GO:0060627 (regulation of vesicle-mediated transport)
GO:0060666 (dichotomous subdivision of terminal units involved in salivary gland branching)
GO:0060978 (angiogenesis involved in coronary vascular morphogenesis)
GO:0060982 (coronary artery morphogenesis)
GO:0061299 (retina vasculature morphogenesis in camera-type eye)
GO:0061441 (renal artery morphogenesis)
GO:0061549 (sympathetic ganglion development)
GO:0061551 (trigeminal ganglion development)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071526 (semaphorin-plexin signaling pathway)
GO:0071679 (commissural neuron axon guidance)
GO:0090259 (regulation of retinal ganglion cell axon guidance)
GO:0097102 (endothelial tip cell fate specification)
GO:0097374 (sensory neuron axon guidance)
GO:0097490 (sympathetic neuron projection extension)
GO:0097491 (sympathetic neuron projection guidance)
GO:1901166 (neural crest cell migration involved in autonomic nervous system development)
GO:1901998 (toxin transport)
GO:1902285 (semaphorin-plexin signaling pathway involved in neuron projection guidance)
GO:1902287 (semaphorin-plexin signaling pathway involved in axon guidance)
GO:1902336 (positive regulation of retinal ganglion cell axon guidance)
GO:1902378 (VEGF-activated neuropilin signaling pathway involved in axon guidance)
GO:1902946 (protein localization to early endosome)
GO:1903375 (facioacoustic ganglion development)
GO:1904835 (dorsal root ganglion morphogenesis)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia Neuropilin_1

Target Cross References - Protein

canSAR O14786
Human Protein Atlas ENSG00000099250
IntAct O14786
Open Targets ENSG00000099250
PharmGKB PA31783
Reactome R-HSA-194306 (Neurophilin interactions with VEGF and VEGFR.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-399955 (SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.)
R-HSA-399956 (CRMPs in Sema3A signaling.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-447041 (CHL1 interactions.)
TIMBAL Neuropilin-1
UniProt B0LPG9 O14786 O60461 Q5T7F1 Q5T7F2 Q5T7F3 Q86T59 Q96I90 Q96IH5

Target Cross References - Domain

InterPro IPR000421 (FA58C.)
IPR000859 (CUB_dom.)
IPR000998 (MAM_dom.)
IPR008979 (Galactose-bd-like.)
IPR013320 (ConA-like_dom.)
IPR014648 (Neuropilin.)
IPR022579 (Neuropilin_C.)
IPR027146 (NRP1.)
Pfam PF00431 (CUB)
PF00629 (MAM)
PF00754 (F5_F8_type_C)
PF11980 (DUF3481)

Target Cross References - Structure

PDBe 1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5L73