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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5147
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-B receptor 4
Synonyms EPHB4 | Ephrin type-B receptor 4 | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 4 SINGLE PROTEIN P54760

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL403989 TG100-801 Ephrin type-B receptor 4 inhibitor 2 PubMed
CHEMBL3544983 TESEVATINIB Ephrin type-B receptor 4 inhibitor 2 Other PubMed PubMed
CHEMBL3545155 JI-101 Ephrin type-B receptor 4 inhibitor 2 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196411
Ensembl ENSG00000196411
GO Cellular Component GO:0005576 (extracellular region)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0003007 (heart morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
Wikipedia EPH_receptor_B4

Target Cross References - Protein

canSAR P54760
Human Protein Atlas ENSG00000196411
IntAct P54760
Guide to Pharmacology 1833
Open Targets ENSG00000196411
PharmGKB PA27827
Pharos P54760 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt B5A970 B5A971 B5A972 P54760 Q7Z635 Q9BTA5 Q9BXP0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07699 (Ephrin_rec_like)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 2BBA 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4
CREDO 2BBA 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4
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