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Target Report Card

Target Name and Classification

Target ID CHEMBL5141
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 26A1
Synonyms CYP26 | CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | Cytochrome P450RAI | P450RAI1 | Retinoic acid 4-hydroxylase | Retinoic acid-metabolizing cytochrome | hP450RAI
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 26 > cytochrome p450 family 26a > cytochrome p450 26a1

Target Components

Component Description Relationship Accession
Cytochrome P450 26A1 SINGLE PROTEIN O43174

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000095596
Ensembl ENSG00000095596
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0001972 (retinoic acid binding)
GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008401 (retinoic acid 4-hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006766 (vitamin metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0034653 (retinoic acid catabolic process)
GO:0042573 (retinoic acid metabolic process)
GO:0048387 (negative regulation of retinoic acid receptor signaling pathway)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP26A1

Target Cross References - Protein

canSAR O43174
Human Protein Atlas ENSG00000095596
Guide to Pharmacology 1366
Open Targets ENSG00000095596
PharmGKB PA27098
Reactome R-HSA-211916 (Vitamins.)
R-HSA-5365859 (RA biosynthesis pathway.)
UniProt B3KNI4 O43174 Q5VXH9 Q5VXI0

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002403 (Cyt_P450_E_grp-IV.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)
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