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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5133
Target Type SINGLE PROTEIN
Preferred Name ADAMTS1
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 1 | ADAM-TS 1 | ADAM-TS1 | ADAMTS-1 | ADAMTS1 | KIAA1346 | METH-1 | METH1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
A disintegrin and metalloproteinase with thrombospondin motifs 1 SINGLE PROTEIN Q9UHI8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154734
Ensembl ENSG00000154734
GO Molecular Function GO:0008201 (heparin binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
Wikipedia ADAMTS1

Target Cross References - Protein

canSAR Q9UHI8
Human Protein Atlas ENSG00000154734
IntAct Q9UHI8
Guide to Pharmacology 1674 (ADAMTS1)
PharmGKB PA24536
UniProt D3DSD5 Q9NSJ8 Q9P2K0 Q9UH83 Q9UHI8 Q9UP80

Target Cross References - Domain

InterPro IPR000884 (Thrombospondin_1_rpt.)
IPR001590 (Peptidase_M12B.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR010294 (ADAM_spacer1.)
IPR013273 (Peptidase_M12B_ADAM-TS.)
IPR013274 (Pept_M12B_ADAM-TS1.)
Pfam PF00090 (TSP_1)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF05986 (ADAM_spacer1)

Target Cross References - Structure

PDBe 2JIH 2V4B 3Q2G 3Q2H
CREDO 2JIH 2V4B 3Q2G 3Q2H
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