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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5121
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase 6
Synonyms ERK-3 | ERK3 | Extracellular signal-regulated kinase 3 | MAP kinase 6 | MAP kinase isoform p97 | MAPK 6 | MAPK6 | Mitogen-activated protein kinase 6 | PRKM6 | p97-MAPK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase erk3

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 6 SINGLE PROTEIN Q16659

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069956
Ensembl ENSG00000069956
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
Wikipedia MAPK6

Target Cross References - Protein

canSAR Q16659
Human Protein Atlas ENSG00000069956
IntAct Q16659
Guide to Pharmacology 2092
Open Targets ENSG00000069956
PharmGKB PA30624
Pharos Q16659 (Tbio)
Reactome R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt B2R945 B5BU65 Q16659 Q68DH4 Q8IYN8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008350 (MAPK_ERK3/4.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2I6L
CREDO 2I6L
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