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Target Report Card

Target Name and Classification

Target ID CHEMBL5119
Target Type SINGLE PROTEIN
Preferred Name Zinc finger protein GLI2
Synonyms GLI family zinc finger protein 2 | GLI2 | THP | Tax helper protein | Zinc finger protein GLI2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Zinc finger protein GLI2 SINGLE PROTEIN P10070

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074047
Ensembl ENSG00000074047
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005929 (cilium)
GO:0005930 (axoneme)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0031512 (motile primary cilium)
GO:0072372 (primary cilium)
GO:0097542 (ciliary tip)
GO:0097546 (ciliary base)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001501 (skeletal system development)
GO:0001649 (osteoblast differentiation)
GO:0001701 (in utero embryonic development)
GO:0001822 (kidney development)
GO:0002009 (morphogenesis of an epithelium)
GO:0002062 (chondrocyte differentiation)
GO:0002076 (osteoblast development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007224 (smoothened signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007389 (pattern specification process)
GO:0007411 (axon guidance)
GO:0007418 (ventral midline development)
GO:0007442 (hindgut morphogenesis)
GO:0007507 (heart development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0009913 (epidermal cell differentiation)
GO:0009952 (anterior/posterior pattern specification)
GO:0009953 (dorsal/ventral pattern formation)
GO:0009954 (proximal/distal pattern formation)
GO:0021508 (floor plate formation)
GO:0021513 (spinal cord dorsal/ventral patterning)
GO:0021517 (ventral spinal cord development)
GO:0021522 (spinal cord motor neuron differentiation)
GO:0021696 (cerebellar cortex morphogenesis)
GO:0021775 (smoothened signaling pathway involved in ventral spinal cord interneuron specification)
GO:0021776 (smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0021915 (neural tube development)
GO:0021938 (smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)
GO:0021965 (spinal cord ventral commissure morphogenesis)
GO:0021983 (pituitary gland development)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030879 (mammary gland development)
GO:0030902 (hindbrain development)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0035295 (tube development)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042733 (embryonic digit morphogenesis)
GO:0043066 (negative regulation of apoptotic process)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045740 (positive regulation of DNA replication)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048566 (embryonic digestive tract development)
GO:0048589 (developmental growth)
GO:0048646 (anatomical structure formation involved in morphogenesis)
GO:0048666 (neuron development)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048856 (anatomical structure development)
GO:0060032 (notochord regression)
GO:0060322 (head development)
GO:0060513 (prostatic bud formation)
GO:0060603 (mammary gland duct morphogenesis)
GO:0060831 (smoothened signaling pathway involved in dorsal/ventral neural tube patterning)
GO:0071407 (cellular response to organic cyclic compound)
GO:0090103 (cochlea morphogenesis)
GO:0098586 (cellular response to virus)
Wikipedia GLI2

Target Cross References - Protein

canSAR P10070
CGD Pituitary insufficiency and postaxial polydactyly
Human Protein Atlas ENSG00000074047
IntAct P10070
Open Targets ENSG00000074047
PharmGKB PA28721
Reactome R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5632684 (Hedgehog 'on' state.)
R-HSA-5635851 (GLI proteins bind promoters of Hh responsive genes to promote transcription.)
UniProt O60252 O60253 O60254 O60255 P10070 Q15590 Q15591 Q4JHT4

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)
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