ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5119
Preferred Name Zinc finger protein GLI2
Synonyms GLI family zinc finger protein 2 | GLI2 | THP | Tax helper protein | Zinc finger protein GLI2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Zinc finger protein GLI2 SINGLE PROTEIN P10070

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074047
Ensembl ENSG00000074047
GO Cellular Component GO:0005634 (nucleus)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016563 (transcription activator activity)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001501 (skeletal system development)
GO:0001649 (osteoblast differentiation)
GO:0001822 (kidney development)
GO:0002076 (osteoblast development)
GO:0007411 (axon guidance)
GO:0007442 (hindgut morphogenesis)
GO:0007507 (heart development)
GO:0008283 (cell proliferation)
GO:0009913 (epidermal cell differentiation)
GO:0009954 (proximal/distal pattern formation)
GO:0021508 (floor plate formation)
GO:0021696 (cerebellar cortex morphogenesis)
GO:0021775 (smoothened signaling pathway involved in ventral spinal cord interneuron specification)
GO:0021965 (spinal cord ventral commissure morphogenesis)
GO:0021983 (pituitary gland development)
GO:0030324 (lung development)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0042475 (odontogenesis of dentine-containing tooth)
GO:0045740 (positive regulation of DNA replication)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048566 (embryonic digestive tract development)
GO:0048589 (developmental growth)
GO:0048754 (branching morphogenesis of a tube)
Wikipedia GLI2

Target Cross References - Protein

canSAR P10070
CGD Pituitary insufficiency and postaxial polydactyly
Human Protein Atlas ENSG00000074047
PharmGKB PA28721
UniProt O60252 O60253 O60254 O60255 P10070 Q15590 Q15591 Q4JHT4

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)