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Target Report Card

Target Name and Classification

Target ID CHEMBL5119
Target Type SINGLE PROTEIN
Preferred Name Zinc finger protein GLI2
Synonyms GLI family zinc finger protein 2 | GLI2 | THP | Tax helper protein | Zinc finger protein GLI2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Zinc finger protein GLI2 SINGLE PROTEIN P10070

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074047
Ensembl ENSG00000074047
GO Cellular Component GO:0005930 (axoneme)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0031512 (motile primary cilium)
GO:0016020 (membrane)
GO:0005634 (nucleus)
GO:0097546 (ciliary base)
GO:0016607 (nuclear speck)
GO:0097542 (ciliary tip)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0043565 (sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0007389 (pattern specification process)
GO:0007442 (hindgut morphogenesis)
GO:0021508 (floor plate formation)
GO:0021938 (smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)
GO:0030902 (hindbrain development)
GO:0045666 (positive regulation of neuron differentiation)
GO:0060513 (prostatic bud formation)
GO:0021696 (cerebellar cortex morphogenesis)
GO:0021776 (smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)
GO:0035295 (tube development)
GO:0045740 (positive regulation of DNA replication)
GO:0001822 (kidney development)
GO:0009954 (proximal/distal pattern formation)
GO:0021517 (ventral spinal cord development)
GO:0021965 (spinal cord ventral commissure morphogenesis)
GO:0009913 (epidermal cell differentiation)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0042733 (embryonic digit morphogenesis)
GO:0048566 (embryonic digestive tract development)
GO:0048589 (developmental growth)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0060831 (smoothened signaling pathway involved in dorsal/ventral neural tube patterning)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0007411 (axon guidance)
GO:0007418 (ventral midline development)
GO:0030324 (lung development)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0002062 (chondrocyte differentiation)
GO:0007507 (heart development)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0021513 (spinal cord dorsal/ventral patterning)
GO:0060032 (notochord regression)
GO:0060603 (mammary gland duct morphogenesis)
GO:0001501 (skeletal system development)
GO:0001649 (osteoblast differentiation)
GO:0001701 (in utero embryonic development)
GO:0002076 (osteoblast development)
GO:0007224 (smoothened signaling pathway)
GO:0008283 (cell proliferation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048666 (neuron development)
GO:0098586 (cellular response to virus)
GO:0021775 (smoothened signaling pathway involved in ventral spinal cord interneuron specification)
GO:0021983 (pituitary gland development)
GO:0030879 (mammary gland development)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0090103 (cochlea morphogenesis)
Wikipedia GLI2

Target Cross References - Protein

canSAR P10070
CGD Pituitary insufficiency and postaxial polydactyly
Human Protein Atlas ENSG00000074047
IntAct P10070
PharmGKB PA28721
UniProt O60253 P10070 Q15591 Q4JHT4 O60252 Q15590 O60254 O60255

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)
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