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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5100
Target Type SINGLE PROTEIN
Preferred Name Kynureninase
Synonyms KYNU | Kynureninase | L-kynurenine hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Kynureninase SINGLE PROTEIN Q16719

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115919
Ensembl ENSG00000115919
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0016787 (hydrolase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0030429 (kynureninase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006569 (tryptophan catabolic process)
GO:0009435 (NAD biosynthetic process)
GO:0019363 (pyridine nucleotide biosynthetic process)
GO:0019441 (tryptophan catabolic process to kynurenine)
GO:0019442 (tryptophan catabolic process to acetyl-CoA)
GO:0019805 (quinolinate biosynthetic process)
GO:0034341 (response to interferon-gamma)
GO:0034354 (de novo NAD biosynthetic process from tryptophan)
GO:0034516 (response to vitamin B6)
GO:0043420 (anthranilate metabolic process)
GO:0097053 (L-kynurenine catabolic process)
Wikipedia Kynureninase

Target Cross References - Protein

canSAR Q16719
Human Protein Atlas ENSG00000115919
IntAct Q16719
Open Targets ENSG00000115919
PharmGKB PA30258
Reactome R-HSA-71240 (Tryptophan catabolism.)
UniProt B2RCZ5 D3DP79 Q16719 Q6I9T2 Q9BVW3

Target Cross References - Domain

InterPro IPR000192 (Aminotrans_V_dom.)
IPR010111 (Kynureninase.)
IPR015421 (PyrdxlP-dep_Trfase_major_sub1.)
IPR015422 (PyrdxlP-dep_Trfase_major_sub2.)
IPR015424 (PyrdxlP-dep_Trfase.)
Pfam PF00266 (Aminotran_5)

Target Cross References - Structure

PDBe 2HZP 3E9K
CREDO 2HZP 3E9K
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