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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5083
Target Type SINGLE PROTEIN
Preferred Name Poly [ADP-ribose] polymerase 3
Synonyms ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Poly [ADP-ribose] polymerase 3 SINGLE PROTEIN Q9Y6F1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3390820 PARP 1, 2 and 3 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000041880
Ensembl ENSG00000041880
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005814 (centriole)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO:0035861 (site of double-strand break)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0003910 (DNA ligase (ATP) activity)
GO:0003950 (NAD+ ADP-ribosyltransferase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO Biological Process GO:0000723 (telomere maintenance)
GO:0006273 (lagging strand elongation)
GO:0006281 (DNA repair)
GO:0006302 (double-strand break repair)
GO:0006471 (protein ADP-ribosylation)
GO:0051103 (DNA ligation involved in DNA repair)
GO:0051106 (positive regulation of DNA ligation)
GO:0060236 (regulation of mitotic spindle organization)
GO:1990166 (protein localization to site of double-strand break)
Wikipedia PARP3

Target Cross References - Protein

canSAR Q9Y6F1
Human Protein Atlas ENSG00000041880
IntAct Q9Y6F1
Guide to Pharmacology 2864
Open Targets ENSG00000041880
PharmGKB PA24593
UniProt Q8NER9 Q96CG2 Q9UG81 Q9Y6F1

Target Cross References - Domain

InterPro IPR004102 (Poly(ADP-ribose)pol_reg_dom.)
IPR008893 (WGR_domain.)
IPR012317 (Poly(ADP-ribose)pol_cat_dom.)
IPR031275 (PARP3.)
IPR036616 (Poly(ADP-ribose)pol_reg_dom_sf.)
IPR036930 (WGR_dom_sf.)
Pfam PF00644 (PARP)
PF02877 (PARP_reg)
PF05406 (WGR)

Target Cross References - Structure

PDBe 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
CREDO 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
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