ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5081
Preferred Name Interleukin-1 receptor-associated kinase 3
Synonyms IL-1 receptor-associated kinase M | IRAK-3 | IRAK-M | IRAK3 | Interleukin-1 receptor-associated kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase irak family

Target Components

Component Description Relationship Accession
Interleukin-1 receptor-associated kinase 3 SINGLE PROTEIN Q9Y616

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090376
Ensembl ENSG00000090376
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0010933 (positive regulation of macrophage tolerance induction)
GO:0010936 (negative regulation of macrophage cytokine production)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032494 (response to peptidoglycan)
GO:0032496 (response to lipopolysaccharide)
GO:0032695 (negative regulation of interleukin-12 production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0034122 (negative regulation of toll-like receptor signaling pathway)
GO:0042177 (negative regulation of protein catabolic process)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0043330 (response to exogenous dsRNA)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045824 (negative regulation of innate immune response)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070498 (interleukin-1-mediated signaling pathway)
Wikipedia IRAK3

Target Cross References - Protein

Human Protein Atlas ENSG00000090376
IntAct Q9Y616
Guide to Pharmacology 2044 (interleukin-1 receptor-associated kinase 3)
PharmGKB PA38431
UniProt B4DQ57 Q9Y616

Target Cross References - Domain

InterPro IPR000488 (Death.)
IPR000719 (Prot_kinase_cat_dom.)
IPR011009 (Kinase-like_dom.)
IPR011029 (DEATH-like.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00531 (Death)