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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5072
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-B receptor 1
Synonyms EK6 | ELK | ELK | EPH tyrosine kinase 2 | EPH-like kinase 6 | EPHB1 | EPHT2 | Ephrin type-B receptor 1 | HEK6 | NET | NET | Neuronally-expressed EPH-related tyrosine kinase | Tyrosine-protein kinase receptor EPH-2 | hEK6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 1 SINGLE PROTEIN P54762

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154928
Ensembl ENSG00000154928
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031901 (early endosome membrane)
GO:0032433 (filopodium tip)
GO:0042995 (cell projection)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005005 (transmembrane-ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008046 (axon guidance receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032403 (protein complex binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001771 (immunological synapse formation)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021545 (cranial nerve development)
GO:0021631 (optic nerve morphogenesis)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0022008 (neurogenesis)
GO:0030010 (establishment of cell polarity)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0031589 (cell-substrate adhesion)
GO:0046328 (regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048593 (camera-type eye morphogenesis)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0051965 (positive regulation of synapse assembly)
GO:0060326 (cell chemotaxis)
GO:0060996 (dendritic spine development)
GO:0060997 (dendritic spine morphogenesis)
GO:0061351 (neural precursor cell proliferation)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:1901214 (regulation of neuron death)
Wikipedia EPH_receptor_B1

Target Cross References - Protein

canSAR P54762
Human Protein Atlas ENSG00000154928
IntAct P54762
Guide to Pharmacology 1830
Open Targets ENSG00000154928
PharmGKB PA27824
Pharos P54762 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A8K593 B3KTB2 B5A969 O43569 O95142 O95143 P54762 Q0VG87

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034231 (EphB1_rcpt_lig-bd.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 3ZFX
CREDO 3ZFX
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