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Target Report Card

Target Name and Classification

Target ID CHEMBL5050
Preferred Name Matrix metalloproteinase-24
Synonyms MMP-24 | MMP24 | MT-MMP 5 | MT5-MMP | MT5MMP | MT5MMP | MTMMP5 | Matrix metalloproteinase-24 | Membrane-type matrix metalloproteinase 5 | Membrane-type-5 matrix metalloproteinase | Processed matrix metalloproteinase-24
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-24 SINGLE PROTEIN Q9Y5R2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125966
Ensembl ENSG00000125966
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0032588 (trans-Golgi network membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008047 (enzyme activator activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0045296 (cadherin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007155 (cell adhesion)
GO:0010001 (glial cell differentiation)
GO:0043085 (positive regulation of catalytic activity)
GO:0044331 (cell-cell adhesion mediated by cadherin)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0097150 (neuronal stem cell population maintenance)
GO:0098609 (cell-cell adhesion)
Wikipedia MMP24

Target Cross References - Protein

canSAR Q9Y5R2
Human Protein Atlas ENSG00000125966
IntAct Q9Y5R2
Open Targets ENSG00000125966
PharmGKB PA30881
Reactome R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt B7ZBG8 Q9H440 Q9Y5R2

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021190 (Pept_M10A.)
IPR021805 (Pept_M10A_metallopeptidase_C.)
IPR024079 (MetalloPept_cat_dom.)
IPR028723 (MMP24.)
IPR033739 (M10A_MMP.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
PF11857 (DUF3377)