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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5048
Target Type SINGLE PROTEIN
Preferred Name Neutral cholesterol ester hydrolase 1
Synonyms AADACL1 | Arylacetamide deacetylase-like 1 | KIAA1363 | NCEH | NCEH1 | Neutral cholesterol ester hydrolase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Neutral cholesterol ester hydrolase 1 SINGLE PROTEIN Q6PIU2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144959
Ensembl ENSG00000144959
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004771 (sterol esterase activity)
GO:0016787 (hydrolase activity)
GO:0017171 (serine hydrolase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008152 (metabolic process)
GO:0009056 (catabolic process)
GO:0016042 (lipid catabolic process)
Wikipedia NCEH1

Target Cross References - Protein

canSAR Q6PIU2
Human Protein Atlas ENSG00000144959
IntAct Q6PIU2
Open Targets ENSG00000144959
PharmGKB PA165697847
Reactome R-HSA-171052 (LDL-mediated lipid transport.)
UniProt B7Z2K4 B7Z3A1 B7Z5U2 B7Z906 B7ZAW6 F5H7K4 Q6PIU2 Q86WZ1 Q9P2I4

Target Cross References - Domain

InterPro IPR013094 (AB_hydrolase_3.)
IPR017157 (Arylacetamide_deacetylase.)
IPR029058 (AB_hydrolase.)
IPR033140 (Lipase_GDXG_put_SER_AS.)
Pfam PF07859 (Abhydrolase_3)
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