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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5037
Target Type SINGLE PROTEIN
Preferred Name Caspase-10
Synonyms Apoptotic protease Mch-4 | CASP-10 | CASP10 | Caspase-10 subunit p12 | Caspase-10 subunit p23/17 | Caspase-10 | FAS-associated death domain protein interleukin-1B-converting enzyme 2 | FLICE2 | ICE-like apoptotic protease 4 | MCH4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-10 SINGLE PROTEIN Q92851

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831289 Caspase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000003400
Ensembl ENSG00000003400
GO Cellular Component GO:0005829 (cytosol)
GO:0031265 (CD95 death-inducing signaling complex)
GO:0097342 (ripoptosome)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035877 (death effector domain binding)
GO:0097199 (cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO Biological Process GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0030225 (macrophage differentiation)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0097190 (apoptotic signaling pathway)
Wikipedia Caspase_10

Target Cross References - Protein

canSAR Q92851
CGD Autoimmune lymphoproliferative syndrome, type IIA
Human Protein Atlas ENSG00000003400
IntAct Q92851
Open Targets ENSG00000003400
PharmGKB PA26084
Reactome R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
R-HSA-75157 (FasL/ CD95L signaling.)
R-HSA-75158 (TRAIL signaling.)
R-HSA-933543 (NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10.)
UniProt Q68HC0 Q6KF62 Q6KF63 Q8IUP5 Q8WYQ8 Q92851 Q99845 Q9Y2U6 Q9Y2U7

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR001875 (DED_dom.)
IPR002138 (Pept_C14_p10.)
IPR011029 (DEATH-like_dom.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR029030 (Caspase-like_dom.)
IPR033139 (Caspase_cys_AS.)
Pfam PF01335 (DED)
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