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Target Report Card

Target Name and Classification

Target ID CHEMBL5037
Preferred Name Caspase-10
Synonyms Apoptotic protease Mch-4 | CASP-10 | CASP10 | Caspase-10 | Caspase-10 subunit p12 | Caspase-10 subunit p23/17 | FAS-associated death domain protein interleukin-1B-converting enzyme 2 | FLICE2 | ICE-like apoptotic protease 4 | MCH4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-10 SINGLE PROTEIN Q92851

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000003400
Ensembl ENSG00000003400
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006915 (apoptosis)
GO:0008624 (induction of apoptosis by extracellular signals)
Wikipedia Caspase_10

Target Cross References - Protein

canSAR Q92851
CGD Autoimmune lymphoproliferative syndrome, type IIA
Human Protein Atlas ENSG00000003400
IntAct Q92851
Guide to Pharmacology 1626 (Caspase 10)
PharmGKB PA26084
Reactome REACT_578 (Apoptosis.)
REACT_6900 (Signaling in Immune system.)
UniProt Q6KF62 Q6KF63 Q8IUP5 Q8WYQ8 Q92851 Q99845 Q9Y2U6 Q9Y2U7

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_ICE_p20.)
IPR001875 (DED.)
IPR002138 (Pept_C14_p10.)
IPR002398 (Pept_C14_p45.)
IPR011029 (DEATH-like.)
IPR011600 (Pept_C14_cat.)
IPR015917 (Pept_C14_p45_core.)
IPR016129 (Pept_C14_ICE_p20_AS.)
Pfam PF00656 (Peptidase_C14)
PF01335 (DED)