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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5037
Preferred Name Caspase-10
Synonyms Apoptotic protease Mch-4 | CASP-10 | CASP10 | Caspase-10 subunit p12 | Caspase-10 subunit p23/17 | Caspase-10 | FAS-associated death domain protein interleukin-1B-converting enzyme 2 | FLICE2 | ICE-like apoptotic protease 4 | MCH4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-10 SINGLE PROTEIN Q92851

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000003400
Ensembl ENSG00000003400
GO Cellular Component GO:0005829 (cytosol)
GO:0031265 (CD95 death-inducing signaling complex)
GO:0097342 (ripoptosome)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035877 (death effector domain binding)
GO:0097199 (cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO Biological Process GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0030225 (macrophage differentiation)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0097190 (apoptotic signaling pathway)
Wikipedia Caspase_10

Target Cross References - Protein

canSAR Q92851
CGD Autoimmune lymphoproliferative syndrome, type IIA
Human Protein Atlas ENSG00000003400
IntAct Q92851
Open Targets ENSG00000003400
PharmGKB PA26084
Reactome R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
R-HSA-75157 (FasL/ CD95L signaling.)
R-HSA-75158 (TRAIL signaling.)
R-HSA-933543 (NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10.)
UniProt Q68HC0 Q6KF62 Q6KF63 Q8IUP5 Q8WYQ8 Q92851 Q99845 Q9Y2U6 Q9Y2U7

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR001875 (DED_dom.)
IPR002138 (Pept_C14_p10.)
IPR011029 (DEATH-like_dom.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR029030 (Caspase-like_dom.)
IPR033139 (Caspase_cys_AS.)
Pfam PF01335 (DED)