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Target Report Card

Target Name and Classification

Target ID CHEMBL5028
Target Type SINGLE PROTEIN
Preferred Name ADAM10
Synonyms ADAM 10 | ADAM10 | CD_antigen=CD156c | CDw156 | Disintegrin and metalloproteinase domain-containing protein 10 | KUZ | Kuzbanian protein homolog | MADM | Mammalian disintegrin-metalloprotease
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 10 SINGLE PROTEIN O14672

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137845
Ensembl ENSG00000137845
GO Cellular Component GO:0005634 (nucleus)
GO:0005798 (Golgi-associated vesicle)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0012505 (endomembrane system)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005178 (integrin binding)
GO:0008270 (zinc ion binding)
GO:0017124 (SH3 domain binding)
GO:0019901 (protein kinase binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0006468 (protein phosphorylation)
GO:0007162 (negative regulation of cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0010820 (positive regulation of T cell chemotaxis)
GO:0030307 (positive regulation of cell growth)
GO:0034612 (response to tumor necrosis factor)
GO:0042117 (monocyte activation)
GO:0051088 (PMA-inducible membrane protein ectodomain proteolysis)
GO:0051089 (constitutive protein ectodomain proteolysis)
Wikipedia ADAM10

Target Cross References - Protein

canSAR O14672
Human Protein Atlas ENSG00000137845
IntAct O14672
Guide to Pharmacology 1658 (ADAM10)
PharmGKB PA24505
Reactome REACT_299 (Signaling by Notch.)
REACT_9417 (Signaling by EGFR.)
UniProt O14672 Q10742 Q92650

Target Cross References - Domain

InterPro IPR001590 (Peptidase_M12B.)
IPR001762 (Blood-coag_inhib_Disintegrin.)
IPR002870 (Peptidase_M12B_N.)
Pfam PF00200 (Disintegrin)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
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