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Target Report Card

Target Name and Classification

Target ID CHEMBL5028
Preferred Name ADAM10
Synonyms ADAM 10 | ADAM10 | CD_antigen=CD156c | CDw156 | Disintegrin and metalloproteinase domain-containing protein 10 | KUZ | Kuzbanian protein homolog | MADM | Mammalian disintegrin-metalloprotease
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 10 SINGLE PROTEIN O14672

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137845
Ensembl ENSG00000137845
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005794 (Golgi apparatus)
GO:0005798 (Golgi-associated vesicle)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0035579 (specific granule membrane)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO:0097038 (perinuclear endoplasmic reticulum)
GO:0097197 (tetraspanin-enriched microdomain)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0005102 (receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0017124 (SH3 domain binding)
GO:0019901 (protein kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0006468 (protein phosphorylation)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007162 (negative regulation of cell adhesion)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0010820 (positive regulation of T cell chemotaxis)
GO:0016485 (protein processing)
GO:0022617 (extracellular matrix disassembly)
GO:0030307 (positive regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0034612 (response to tumor necrosis factor)
GO:0035333 (Notch receptor processing, ligand-dependent)
GO:0042117 (monocyte activation)
GO:0043312 (neutrophil degranulation)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0051088 (PMA-inducible membrane protein ectodomain proteolysis)
GO:0051089 (constitutive protein ectodomain proteolysis)
Wikipedia ADAM10

Target Cross References - Protein

canSAR O14672
Human Protein Atlas ENSG00000137845
IntAct O14672
Guide to Pharmacology 1658
Open Targets ENSG00000137845
PharmGKB PA24505
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-177929 (Signaling by EGFR.)
R-HSA-1980150 (Signaling by NOTCH4.)
R-HSA-2122948 (Activated NOTCH1 Transmits Signal to the Nucleus.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2660826 (Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.)
R-HSA-2691232 (Constitutive Signaling by NOTCH1 HD Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-2979096 (NOTCH2 Activation and Transmission of Signal to the Nucleus.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
R-HSA-9013507 (NOTCH3 Activation and Transmission of Signal to the Nucleus.)
UniProt B4DU28 O14672 Q10742 Q92650

Target Cross References - Domain

InterPro IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR027053 (ADAM_10.)
IPR034025 (ADAM10_ADAM17.)
IPR036436 (Disintegrin_dom_sf.)
Pfam PF00200 (Disintegrin)
PF01562 (Pep_M12B_propep)

Target Cross References - Structure