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Target Report Card

Target Name and Classification

Target ID CHEMBL5027
Preferred Name Flap endonuclease 1
Synonyms DNase IV | FEN-1 | FEN1 | Flap endonuclease 1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Flap endonuclease 1 SINGLE PROTEIN P39748

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168496
Ensembl ENSG00000168496
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005739 (mitochondrion)
GO Molecular Function GO:0003684 (damaged DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0004523 (ribonuclease H activity)
GO:0005515 (protein binding)
GO:0008309 (double-stranded DNA specific exodeoxyribonuclease activity)
GO:0008409 (5'-3' exonuclease activity)
GO:0017108 (5'-flap endonuclease activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000084 (S phase of mitotic cell cycle)
GO:0000722 (telomere maintenance via recombination)
GO:0006284 (base-excision repair)
GO:0006302 (double-strand break repair)
GO:0009650 (UV protection)
GO:0032201 (telomere maintenance via semi-conservative replication)
GO:0043137 (DNA replication, removal of RNA primer)
GO:0048015 (phosphatidylinositol-mediated signaling)
Wikipedia Flap_structure-specific_endonuclease_1

Target Cross References - Protein

canSAR P39748
Human Protein Atlas ENSG00000168496
IntAct P39748
PharmGKB PA28090
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_216 (DNA Repair.)
REACT_22172 (Chromosome Maintenance.)
REACT_383 (DNA Replication.)

Target Cross References - Domain

InterPro IPR006084 (XPGC_Rad_DNA_repair.)
IPR006085 (XPG_DNA_repair_N.)
IPR006086 (XPG/RAD2_endonuclease.)
IPR008918 (HhH2.)
IPR019974 (XPG_CS.)
IPR020045 (5-3_exonuclease_C.)
IPR023426 (Flap_structure-sp_endonuc.)
Pfam PF00752 (XPG_N)
PF00867 (XPG_I)

Target Cross References - Structure

PDBe 1U7B 1UL1 3Q8K 3Q8L 3Q8M
CREDO 1U7B 1UL1 3Q8K 3Q8L 3Q8M