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Target Report Card

Target Name and Classification

Target ID CHEMBL5027
Preferred Name Flap endonuclease 1
Synonyms DNase IV | FEN-1 | FEN1 | Flap endonuclease 1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Flap endonuclease 1 SINGLE PROTEIN P39748

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168496
Ensembl ENSG00000168496
GO Cellular Component GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0043234 (protein complex)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003824 (catalytic activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004523 (RNA-DNA hybrid ribonuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0008309 (double-stranded DNA exodeoxyribonuclease activity)
GO:0008409 (5'-3' exonuclease activity)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0017108 (5'-flap endonuclease activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000722 (telomere maintenance via recombination)
GO:0000724 (double-strand break repair via homologous recombination)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006302 (double-strand break repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007613 (memory)
GO:0009650 (UV protection)
GO:0043137 (DNA replication, removal of RNA primer)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)
Wikipedia Flap_structure-specific_endonuclease_1

Target Cross References - Protein

canSAR P39748
Human Protein Atlas ENSG00000168496
IntAct P39748
Open Targets ENSG00000168496
PharmGKB PA28090
Reactome R-HSA-110362 (POLB-Dependent Long Patch Base Excision Repair.)
R-HSA-162594 (Early Phase of HIV Life Cycle.)
R-HSA-174437 (Removal of the Flap Intermediate from the C-strand.)
R-HSA-5651801 (PCNA-Dependent Long Patch Base Excision Repair.)
R-HSA-5685939 (HDR through MMEJ (alt-NHEJ).)
R-HSA-69166 (Removal of the Flap Intermediate.)
UniProt P39748

Target Cross References - Domain

InterPro IPR006084 (XPG/Rad2.)
IPR006085 (XPG_DNA_repair_N.)
IPR006086 (XPG-I_dom.)
IPR008918 (HhH2.)
IPR019974 (XPG_CS.)
IPR020045 (5-3_exonuclease_C.)
IPR023426 (Flap_endonuc.)
IPR029060 (PIN_domain-like.)
Pfam PF00752 (XPG_N)
PF00867 (XPG_I)

Target Cross References - Structure

PDBe 1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7
CREDO 1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7