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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5026
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase EEF2K
Synonyms Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | Eukaryotic elongation factor 2 kinase | eEF-2 kinase | eEF-2K
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase alpha family

Target Components

Component Description Relationship Accession
Eukaryotic elongation factor 2 kinase SINGLE PROTEIN O00418

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103319
Ensembl ENSG00000103319
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0014069 (postsynaptic density)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004686 (elongation factor-2 kinase activity)
GO:0005509 (calcium ion binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0008135 (translation factor activity, RNA binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002931 (response to ischemia)
GO:0006414 (translational elongation)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0031952 (regulation of protein autophosphorylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0043066 (negative regulation of apoptotic process)
GO:0045807 (positive regulation of endocytosis)
GO:0046777 (protein autophosphorylation)
GO:0051965 (positive regulation of synapse assembly)
GO:0061003 (positive regulation of dendritic spine morphogenesis)
GO:0071277 (cellular response to calcium ion)
GO:0071320 (cellular response to cAMP)
GO:0071454 (cellular response to anoxia)
GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus)
GO:1990637 (response to prolactin)
Wikipedia EEF2K

Target Cross References - Protein

canSAR O00418
Human Protein Atlas ENSG00000103319
IntAct O00418
Guide to Pharmacology 2014
Open Targets ENSG00000103319
PharmGKB PA134992891
Pharos O00418 (Tbio)
Reactome R-HSA-166208 (mTORC1-mediated signalling.)
UniProt O00418 Q8N588

Target Cross References - Domain

InterPro IPR004166 (MHCK_EF2_kinase.)
IPR006597 (Sel1-like.)
IPR011009 (Kinase-like_dom.)
IPR011990 (TPR-like_helical_dom.)
IPR017400 (eEF-2K.)
Pfam PF02816 (Alpha_kinase)
PF08238 (Sel1)
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