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Target Report Card

Target Name and Classification

Target ID CHEMBL5024
Target Type SINGLE PROTEIN
Preferred Name Serine-protein kinase ATR
Synonyms ATR | Ataxia telangiectasia and Rad3-related protein | FRAP-related protein 1 | FRP1 | Serine/threonine-protein kinase ATR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase pikk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase ATR SINGLE PROTEIN Q13535

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545202 VX-970 Serine-protein kinase ATR inhibitor 2 PubMed PubMed
CHEMBL3545178 AZD-6738 Serine-protein kinase ATR inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175054
Ensembl ENSG00000175054
GO Cellular Component GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005794 (Golgi apparatus)
GO:0016605 (PML body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032405 (MutLalpha complex binding)
GO:0032407 (MutSalpha complex binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007275 (multicellular organism development)
GO:0008156 (negative regulation of DNA replication)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0034644 (cellular response to UV)
GO:0036297 (interstrand cross-link repair)
GO:0042493 (response to drug)
GO:0043517 (positive regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0046777 (protein autophosphorylation)
GO:0070198 (protein localization to chromosome, telomeric region)
GO:0071480 (cellular response to gamma radiation)
GO:0090399 (replicative senescence)
GO:0097694 (establishment of RNA localization to telomere)
GO:0097695 (establishment of macromolecular complex localization to telomere)
GO:1900034 (regulation of cellular response to heat)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904884 (positive regulation of telomerase catalytic core complex assembly)
Wikipedia Ataxia_telangiectasia_and_Rad3_related

Target Cross References - Protein

canSAR Q13535
CGD Cutaneous telangiectasia and cancer syndrome, familial; Seckel syndrome 1
Human Protein Atlas ENSG00000175054
IntAct Q13535
Guide to Pharmacology 1935
Open Targets ENSG00000175054
PharmGKB PA74
Pharos Q13535 (Tchem)
Reactome R-HSA-1221632 (Meiotic synapsis.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-5685938 (HDR through Single Strand Annealing (SSA).)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5693616 (Presynaptic phase of homologous DNA pairing and strand exchange.)
R-HSA-6783310 (Fanconi Anemia Pathway.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
UniProt Q13535 Q59HB2 Q7KYL3 Q93051 Q9BXK4

Target Cross References - Domain

InterPro IPR000403 (PI3/4_kinase_cat_dom.)
IPR003151 (PIK-rel_kinase_FAT.)
IPR003152 (FATC_dom.)
IPR011009 (Kinase-like_dom.)
IPR011989 (ARM-like.)
IPR011990 (TPR-like_helical_dom.)
IPR012993 (UME.)
IPR014009 (PIK_FAT.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR021133 (HEAT_type_2.)
Pfam PF00454 (PI3_PI4_kinase)
PF02259 (FAT)
PF02260 (FATC)
PF08064 (UME)
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