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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5023
Target Type SINGLE PROTEIN
Preferred Name p53-binding protein Mdm-2
Synonyms Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | Hdm2 | MDM2 | Oncoprotein Mdm2 | RING-type E3 ubiquitin transferase Mdm2 | p53-binding protein Mdm2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
E3 ubiquitin-protein ligase Mdm2 SINGLE PROTEIN Q00987

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907611 Tumour suppressor p53/oncoprotein Mdm2 PROTEIN-PROTEIN INTERACTION
CHEMBL3038493 Casein kinase I/MDM2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135679
Ensembl ENSG00000135679
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016604 (nuclear body)
GO:0030666 (endocytic vesicle membrane)
GO:0043234 (protein complex)
GO:0045202 (synapse)
GO Molecular Function GO:0002039 (p53 binding)
GO:0004842 (ubiquitin-protein transferase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016874 (ligase activity)
GO:0019789 (SUMO transferase activity)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0046872 (metal ion binding)
GO:0061630 (ubiquitin protein ligase activity)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001568 (blood vessel development)
GO:0001974 (blood vessel remodeling)
GO:0002027 (regulation of heart rate)
GO:0003170 (heart valve development)
GO:0003181 (atrioventricular valve morphogenesis)
GO:0003203 (endocardial cushion morphogenesis)
GO:0003281 (ventricular septum development)
GO:0003283 (atrial septum development)
GO:0006461 (protein complex assembly)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007089 (traversing start control point of mitotic cell cycle)
GO:0007507 (heart development)
GO:0008284 (positive regulation of cell proliferation)
GO:0009636 (response to toxic substance)
GO:0009743 (response to carbohydrate)
GO:0010039 (response to iron ion)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010955 (negative regulation of protein processing)
GO:0016032 (viral process)
GO:0016567 (protein ubiquitination)
GO:0016925 (protein sumoylation)
GO:0018205 (peptidyl-lysine modification)
GO:0031648 (protein destabilization)
GO:0032026 (response to magnesium ion)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0034504 (protein localization to nucleus)
GO:0042176 (regulation of protein catabolic process)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042787 (protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043278 (response to morphine)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0045184 (establishment of protein localization)
GO:0045472 (response to ether)
GO:0045787 (positive regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046677 (response to antibiotic)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0048545 (response to steroid hormone)
GO:0060411 (cardiac septum morphogenesis)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0071236 (cellular response to antibiotic)
GO:0071301 (cellular response to vitamin B1)
GO:0071310 (cellular response to organic substance)
GO:0071312 (cellular response to alkaloid)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071391 (cellular response to estrogen stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071456 (cellular response to hypoxia)
GO:0071494 (cellular response to UV-C)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1901797 (negative regulation of signal transduction by p53 class mediator)
Wikipedia Mdm2

Target Cross References - Protein

canSAR Q00987
Human Protein Atlas ENSG00000135679
IntAct Q00987
Open Targets ENSG00000135679
PharmGKB PA30718
Reactome R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-3232118 (SUMOylation of transcription factors.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-69541 (Stabilization of p53.)
TIMBAL MDM2
UniProt A6NL51 A8K2S6 Q00987 Q13226 Q13297 Q13298 Q13299 Q13300 Q13301 Q53XW0 Q71TW9 Q8WYJ1 Q8WYJ2 Q9UGI3 Q9UMT8

Target Cross References - Domain

InterPro IPR001841 (Znf_RING.)
IPR001876 (Znf_RanBP2.)
IPR003121 (SWIB_MDM2_domain.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR015459 (MDM2_E3_ligase.)
IPR016495 (p53_neg-reg_MDM_2/4.)
IPR028340 (Mdm2.)
Pfam PF00641 (zf-RanBP)
PF02201 (SWIB)

Target Cross References - Structure

PDBe 1RV1 1T4E 1T4F 1YCR 2AXI 2F1Y 2FOP 2GV2 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX More...
CREDO 1RV1 1T4E 1T4F 1YCR 2AXI 2F1Y 2FOP 2GV2 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX More...
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