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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5023
Target Type SINGLE PROTEIN
Preferred Name p53-binding protein Mdm-2
Synonyms Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | Hdm2 | MDM2 | Oncoprotein Mdm2 | p53-binding protein Mdm2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
E3 ubiquitin-protein ligase Mdm2 SINGLE PROTEIN Q00987

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907611 Tumour suppressor p53/oncoprotein Mdm2 PROTEIN-PROTEIN INTERACTION
CHEMBL3038493 Casein kinase I/MDM2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135679
Ensembl ENSG00000135679
GO Cellular Component GO:0005626 (insoluble fraction)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0030666 (endocytic vesicle membrane)
GO:0043234 (protein complex)
GO Molecular Function GO:0002039 (p53 binding)
GO:0004842 (ubiquitin-protein ligase activity)
GO:0008270 (zinc ion binding)
GO:0017163 (basal transcription repressor activity)
GO:0019899 (enzyme binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006461 (protein complex assembly)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007268 (synaptic transmission)
GO:0008284 (positive regulation of cell proliferation)
GO:0031648 (protein destabilization)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0034504 (protein localization to nucleus)
GO:0042787 (protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0043066 (negative regulation of apoptosis)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0044419 (interspecies interaction between organisms)
GO:0045184 (establishment of protein localization)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046677 (response to antibiotic)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0071456 (cellular response to hypoxia)
Wikipedia Mdm2

Target Cross References - Protein

canSAR Q00987
Human Protein Atlas ENSG00000135679
IntAct Q00987
PharmGKB PA30718
Reactome REACT_11061 (Signalling by NGF.)
REACT_13685 (Synaptic Transmission.)
REACT_1538 (Cell Cycle Checkpoints.)
TIMBAL MDM2
UniProt A6NL51 A8K2S6 Q00987 Q13226 Q13297 Q13298 Q13299 Q13300 Q13301 Q53XW0 Q71TW9 Q8WYJ1 Q8WYJ2 Q9UGI3 Q9UMT8

Target Cross References - Domain

InterPro IPR001841 (Znf_RING.)
IPR001876 (Znf_RanBP2.)
IPR003121 (SWIB_MDM2_domain.)
IPR016495 (p53_neg-reg_MDM_2/4.)
Pfam PF00641 (zf-RanBP)
PF02201 (SWIB)

Target Cross References - Structure

PDBe 1RV1 1T4E 1T4F 1YCR 2AXI 2F1Y 2FOP 2GV2 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ
CREDO 1RV1 1T4E 1T4F 1YCR 2AXI 2F1Y 2FOP 2GV2 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ
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