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Target Report Card

Target Name and Classification

Target ID CHEMBL5021
Target Type SINGLE PROTEIN
Preferred Name CDK-interacting protein 1
Synonyms CAP20 | CDK-interacting protein 1 | CDKN1 | CDKN1A | CIP1 | Cyclin-dependent kinase inhibitor 1 | MDA-6 | MDA6 | Melanoma differentiation-associated protein 6 | PIC1 | SDI1 | WAF1 | p21
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase inhibitor 1 SINGLE PROTEIN P38936

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038463 AKT/p21CIP1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124762
Ensembl ENSG00000124762
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070557 (PCNA-p21 complex)
GO Molecular Function GO:0004860 (protein kinase inhibitor activity)
GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity)
GO:0005515 (protein binding)
GO:0019912 (cyclin-dependent protein kinase activating kinase activity)
GO:0030332 (cyclin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032403 (protein complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007265 (Ras protein signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008285 (negative regulation of cell proliferation)
GO:0009411 (response to UV)
GO:0009636 (response to toxic substance)
GO:0010033 (response to organic substance)
GO:0010165 (response to X-ray)
GO:0010243 (response to organonitrogen compound)
GO:0010629 (negative regulation of gene expression)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0030308 (negative regulation of cell growth)
GO:0030890 (positive regulation of B cell proliferation)
GO:0031100 (organ regeneration)
GO:0031668 (cellular response to extracellular stimulus)
GO:0033158 (regulation of protein import into nucleus, translocation)
GO:0034198 (cellular response to amino acid starvation)
GO:0034605 (cellular response to heat)
GO:0042326 (negative regulation of phosphorylation)
GO:0042493 (response to drug)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0043066 (negative regulation of apoptotic process)
GO:0043068 (positive regulation of programmed cell death)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0046685 (response to arsenic-containing substance)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050821 (protein stabilization)
GO:0051384 (response to glucocorticoid)
GO:0051412 (response to corticosterone)
GO:0051726 (regulation of cell cycle)
GO:0055093 (response to hyperoxia)
GO:0060574 (intestinal epithelial cell maturation)
GO:0071479 (cellular response to ionizing radiation)
GO:0071493 (cellular response to UV-B)
GO:0071850 (mitotic cell cycle arrest)
GO:0072331 (signal transduction by p53 class mediator)
GO:0090398 (cellular senescence)
GO:0090399 (replicative senescence)
GO:0090400 (stress-induced premature senescence)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:1904031 (positive regulation of cyclin-dependent protein kinase activity)
GO:2000134 (negative regulation of G1/S transition of mitotic cell cycle)
GO:2000278 (regulation of DNA biosynthetic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia P21

Target Cross References - Protein

canSAR P38936
Human Protein Atlas ENSG00000124762
IntAct P38936
Open Targets ENSG00000124762
PharmGKB PA104
Reactome R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69563 (p53-Dependent G1 DNA Damage Response.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-69895 (Transcriptional activation of cell cycle inhibitor p21.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-8866911 (TFAP2 (AP-2) family regulates transcription of cell cycle factors.)
UniProt P38936 Q14010 Q6FI05 Q9BUT4

Target Cross References - Domain

InterPro IPR003175 (CDI.)
IPR029841 (CDKN1A_vertebrate.)
Pfam PF02234 (CDI)

Target Cross References - Structure

PDBe 1AXC 2ZVV 2ZVW 4RJF 5E0U
CREDO 1AXC 2ZVV 2ZVW 4RJF 5E0U
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