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Target Report Card

Target Name and Classification

Target ID CHEMBL5002
Preferred Name Nuclear receptor subfamily 4 group A member 2
Synonyms Immediate-early response protein NOT | NOT | NR4A2 | NURR1 | Nuclear receptor subfamily 4 group A member 2 | Orphan nuclear receptor NURR1 | TINUR | Transcriptionally-inducible nuclear receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 4 > nuclear hormone receptor subfamily 4 group a > nuclear hormone receptor subfamily 4 group a member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 4 group A member 2 SINGLE PROTEIN P43354

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000153234
Ensembl ENSG00000153234
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008270 (zinc ion binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0001764 (neuron migration)
GO:0001975 (response to amphetamine)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0007399 (nervous system development)
GO:0008344 (adult locomotory behavior)
GO:0009791 (post-embryonic development)
GO:0010467 (gene expression)
GO:0010468 (regulation of gene expression)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0021953 (central nervous system neuron differentiation)
GO:0021986 (habenula development)
GO:0030182 (neuron differentiation)
GO:0030522 (intracellular receptor signaling pathway)
GO:0031668 (cellular response to extracellular stimulus)
GO:0034599 (cellular response to oxidative stress)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042416 (dopamine biosynthetic process)
GO:0042417 (dopamine metabolic process)
GO:0042551 (neuron maturation)
GO:0043085 (positive regulation of catalytic activity)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043576 (regulation of respiratory gaseous exchange)
GO:0045444 (fat cell differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051866 (general adaptation syndrome)
GO:0060070 (canonical Wnt signaling pathway)
GO:0071376 (cellular response to corticotropin-releasing hormone stimulus)
GO:0071542 (dopaminergic neuron differentiation)
GO:1904948 (midbrain dopaminergic neuron differentiation)
GO:2001234 (negative regulation of apoptotic signaling pathway)
Wikipedia Nuclear_receptor_related_1_protein

Target Cross References - Protein

canSAR P43354
Human Protein Atlas ENSG00000153234
IntAct P43354
Open Targets ENSG00000153234
PharmGKB PA31762
Pharos P43354 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt P43354 Q16311 Q53RZ2 Q6NXU0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003070 (Nuc_orph_rcpt.)
IPR003073 (NURR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure