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Target Report Card

Target Name and Classification

Target ID CHEMBL4999
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member C4
Synonyms 3-alpha-HSD1 | 3-alpha-hydroxysteroid dehydrogenase type I | AKR1C4 | Aldo-keto reductase family 1 member C4 | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C4 SINGLE PROTEIN P17516

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198610
Ensembl ENSG00000198610
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001758 (retinal dehydrogenase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0009055 (electron carrier activity)
GO:0015125 (bile acid transmembrane transporter activity)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0047023 (androsterone dehydrogenase activity)
GO:0047743 (chlordecone reductase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006699 (bile acid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008209 (androgen metabolic process)
GO:0015721 (bile acid and bile salt transport)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0071395 (cellular response to jasmonic acid stimulus)
Wikipedia 3-alpha-HSD

Target Cross References - Protein

Human Protein Atlas ENSG00000198610
Open Targets ENSG00000198610
PharmGKB PA24680
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt P17516 Q5T6A3 Q8WW84 Q9NS54

Target Cross References - Domain

InterPro IPR001395 (Aldo/ket_red/Kv-b.)
IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 2FVL
CREDO 2FVL
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