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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4998
Target Type SINGLE PROTEIN
Preferred Name Integrin alpha-2
Synonyms CD49 antigen-like family member B | CD49B | CD_antigen=CD49b | Collagen receptor | GPIa | ITGA2 | Integrin alpha-2 | Platelet membrane glycoprotein Ia | VLA-2 subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Integrin alpha-2 SINGLE PROTEIN P17301

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111461 Integrin alpha-2/beta-3 PROTEIN COMPLEX
CHEMBL3137268 Integrin alpha2/beta1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743086 VATELIZUMAB Integrin alpha-2 antagonist 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164171
Ensembl ENSG00000164171
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0034666 (integrin alpha2-beta1 complex)
GO:0042995 (cell projection)
GO:0043679 (axon terminus)
GO:0045178 (basal part of cell)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0001618 (virus receptor activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0038064 (collagen receptor activity)
GO:0043236 (laminin binding)
GO:0043395 (heparan sulfate proteoglycan binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0098639 (collagen binding involved in cell-matrix adhesion)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002687 (positive regulation of leukocyte migration)
GO:0006929 (substrate-dependent cell migration)
GO:0006971 (hypotonic response)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007565 (female pregnancy)
GO:0007596 (blood coagulation)
GO:0008283 (cell proliferation)
GO:0009887 (organ morphogenesis)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010694 (positive regulation of alkaline phosphatase activity)
GO:0014070 (response to organic cyclic compound)
GO:0014075 (response to amine)
GO:0014850 (response to muscle activity)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016032 (viral process)
GO:0030198 (extracellular matrix organization)
GO:0030879 (mammary gland development)
GO:0031346 (positive regulation of cell projection organization)
GO:0031589 (cell-substrate adhesion)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033343 (positive regulation of collagen binding)
GO:0033591 (response to L-ascorbic acid)
GO:0033627 (cell adhesion mediated by integrin)
GO:0038065 (collagen-activated signaling pathway)
GO:0042060 (wound healing)
GO:0042493 (response to drug)
GO:0043388 (positive regulation of DNA binding)
GO:0043589 (skin morphogenesis)
GO:0045184 (establishment of protein localization)
GO:0045727 (positive regulation of translation)
GO:0045785 (positive regulation of cell adhesion)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046718 (viral entry into host cell)
GO:0048041 (focal adhesion assembly)
GO:0048333 (mesodermal cell differentiation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050729 (positive regulation of inflammatory response)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051971 (positive regulation of transmission of nerve impulse)
GO:0060100 (positive regulation of phagocytosis, engulfment)
GO:0070365 (hepatocyte differentiation)
GO:0071107 (response to parathyroid hormone)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071407 (cellular response to organic cyclic compound)
Wikipedia CD49b

Target Cross References - Protein

canSAR P17301
Human Protein Atlas ENSG00000164171
IntAct P17301
Guide to Pharmacology 2441
Open Targets ENSG00000164171
PharmGKB PA204
Reactome R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-447041 (CHL1 interactions.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
R-HSA-8874081 (MET activates PTK2 signaling.)
TIMBAL Integrins
UniProt P17301 Q14595

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR002035 (VWF_A.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
IPR036465 (vWFA_dom_sf.)
Pfam PF00092 (VWA)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1AOX 1DZI 1V7P 4BJ3 5HJ2 5THP
CREDO 1AOX 1DZI 1V7P 4BJ3 5HJ2 5THP
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