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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4979
Target Type SINGLE PROTEIN
Preferred Name Sodium/glucose cotransporter 1
Synonyms High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SGLT1 | SLC5A1 | Sodium/glucose cotransporter 1 | Solute carrier family 5 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc05 family of sodium-dependent glucose transporters

Target Components

Component Description Relationship Accession
Sodium/glucose cotransporter 1 SINGLE PROTEIN P13866

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3039507 SOTAGLIFLOZIN Sodium/glucose cotransporter 1 inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100170
Ensembl ENSG00000100170
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005412 (glucose:sodium symporter activity)
GO:0005515 (protein binding)
GO:0015293 (symporter activity)
GO:0022857 (transmembrane transporter activity)
GO Biological Process GO:0001951 (intestinal D-glucose absorption)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0008643 (carbohydrate transport)
GO:0055085 (transmembrane transport)
GO:0106001 (intestinal hexose absorption)
GO:1904659 (glucose transmembrane transport)
Wikipedia SLC5A1

Target Cross References - Protein

canSAR P13866
CGD Glucose/galactose malabsorption
Human Protein Atlas ENSG00000100170
IntAct P13866
Guide to Pharmacology 915
Open Targets ENSG00000100170
PharmGKB PA308
Reactome R-HSA-189200 (Cellular hexose transport.)
R-HSA-5656364 (Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM).)
R-HSA-8981373 (Intestinal hexose absorption.)
UniProt B2R7E2 B7Z4Q9 B7ZA69 P13866

Target Cross References - Domain

InterPro IPR001734 (Na/solute_symporter.)
IPR018212 (Na/solute_symporter_CS.)
Pfam PF00474 (SSF)
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