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Target Report Card

Target Name and Classification

Target ID CHEMBL4977
Target Type SINGLE PROTEIN
Preferred Name Proto-oncogene c-JUN
Synonyms AP1 | Activator protein 1 | JUN | Proto-oncogene c-Jun | Transcription factor AP-1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor AP-1 SINGLE PROTEIN P05412

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111421 Transcription factor AP1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177606
Ensembl ENSG00000177606
GO Cellular Component GO:0000228 (nuclear chromosome)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005719 (nuclear euchromatin)
GO:0005829 (cytosol)
GO:0017053 (transcriptional repressor complex)
GO:0035976 (AP1 complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0000982 (transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001190 (transcriptional activator activity, RNA polymerase II transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003713 (transcription coactivator activity)
GO:0003723 (RNA binding)
GO:0005096 (GTPase activator activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0033613 (activating transcription factor binding)
GO:0035497 (cAMP response element binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0070412 (R-SMAD binding)
GO:0071837 (HMG box domain binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001774 (microglial cell activation)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0001889 (liver development)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0003151 (outflow tract morphogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007623 (circadian rhythm)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0009612 (response to mechanical stimulus)
GO:0009987 (cellular process)
GO:0010033 (response to organic substance)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0014070 (response to organic cyclic compound)
GO:0030224 (monocyte differentiation)
GO:0031103 (axon regeneration)
GO:0031953 (negative regulation of protein autophosphorylation)
GO:0032496 (response to lipopolysaccharide)
GO:0032870 (cellular response to hormone stimulus)
GO:0034097 (response to cytokine)
GO:0034614 (cellular response to reactive oxygen species)
GO:0035026 (leading edge cell differentiation)
GO:0035994 (response to muscle stretch)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043392 (negative regulation of DNA binding)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0043922 (negative regulation by host of viral transcription)
GO:0043923 (positive regulation by host of viral transcription)
GO:0045597 (positive regulation of cell differentiation)
GO:0045657 (positive regulation of monocyte differentiation)
GO:0045740 (positive regulation of DNA replication)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051365 (cellular response to potassium ion starvation)
GO:0051591 (response to cAMP)
GO:0051726 (regulation of cell cycle)
GO:0051899 (membrane depolarization)
GO:0060395 (SMAD protein signal transduction)
GO:0061029 (eyelid development in camera-type eye)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071276 (cellular response to cadmium ion)
GO:0071277 (cellular response to calcium ion)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:1990441 (negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)
GO:2000144 (positive regulation of DNA-templated transcription, initiation)
Wikipedia C-jun

Target Cross References - Protein

canSAR P05412
Human Protein Atlas ENSG00000177606
IntAct P05412
Open Targets ENSG00000177606
PharmGKB PA30006
Reactome R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
R-HSA-8943724 (Regulation of PTEN gene transcription.)
UniProt P05412 Q6FHM7 Q96G93

Target Cross References - Domain

InterPro IPR002112 (Leuzip_Jun.)
IPR004827 (bZIP.)
IPR005643 (JNK.)
IPR008917 (TF_DNA-bd_sf.)
IPR015558 (C_Jun/v-Jun.)
Pfam PF00170 (bZIP_1)
PF03957 (Jun)

Target Cross References - Structure

PDBe 1A02 1FOS 1JNM 1S9K 1T2K 5FV8 5T01
CREDO 1A02 1FOS 1JNM 1S9K 1T2K 5FV8 5T01
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