ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4973
Preferred Name Excitatory amino acid transporter 2
Synonyms EAAT2 | Excitatory amino acid transporter 2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc01 family of amino acid transporters

Target Components

Component Description Relationship Accession
Excitatory amino acid transporter 2 SINGLE PROTEIN P43004

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110436
Ensembl ENSG00000110436
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030673 (axolemma)
GO Molecular Function GO:0005313 (L-glutamate transmembrane transporter activity)
GO:0005314 (high-affinity glutamate transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0008509 (anion transmembrane transporter activity)
GO:0015171 (amino acid transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0015501 (glutamate:sodium symporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0007632 (visual behavior)
GO:0009416 (response to light stimulus)
GO:0009611 (response to wounding)
GO:0010259 (multicellular organism aging)
GO:0014047 (glutamate secretion)
GO:0015813 (L-glutamate transport)
GO:0021537 (telencephalon development)
GO:0030534 (adult behavior)
GO:0031668 (cellular response to extracellular stimulus)
GO:0035264 (multicellular organism growth)
GO:0042493 (response to drug)
GO:0043200 (response to amino acid)
GO:0046326 (positive regulation of glucose import)
GO:0051938 (L-glutamate import)
GO:0070779 (D-aspartate import)
GO:0089711 (L-glutamate transmembrane transport)
GO:0098656 (anion transmembrane transport)
Wikipedia SLC1A2

Target Cross References - Protein

canSAR P43004
Human Protein Atlas ENSG00000110436
IntAct P43004
Guide to Pharmacology 869
Open Targets ENSG00000110436
PharmGKB PA35827
Reactome R-HSA-210455 (Astrocytic Glutamate-Glutamine Uptake And Metabolism.)
R-HSA-210500 (Glutamate Neurotransmitter Release Cycle.)
R-HSA-425393 (Transport of inorganic cations/anions and amino acids/oligopeptides.)
UniProt B4DQE9 P43004 Q14417 Q541G6 U3KQQ4

Target Cross References - Domain

InterPro IPR001991 (Na-dicarboxylate_symporter.)
IPR018107 (Na-dicarboxylate_symporter_CS.)
Pfam PF00375 (SDF)