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Target Report Card

Target Name and Classification

Target ID CHEMBL4967
Target Type SINGLE PROTEIN
Preferred Name NF-kappa-B essential modulator
Synonyms FIP-3 | FIP3 | I-kappa-B kinase subunit gamma | IKBKG | IKK-gamma | IKKAP1 | IKKG | IkB kinase subunit gamma | IkB kinase-associated protein 1 | Inhibitor of nuclear factor kappa-B kinase subunit gamma | NEMO | NEMO | NF-kappa-B essential modifier | NF-kappa-B essential modulator
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
NF-kappa-B essential modulator SINGLE PROTEIN Q9Y6K9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111328 Inhibitor of NF-kappa-B kinase (IKK) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000269335
Ensembl ENSG00000269335
GO Cellular Component GO:0000151 (ubiquitin ligase complex)
GO:0000922 (spindle pole)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0008385 (IkappaB kinase complex)
GO:0072686 (mitotic spindle)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0019904 (protein domain specific binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042803 (protein homodimerization activity)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0070530 (K63-linked polyubiquitin binding)
GO:1990450 (linear polyubiquitin binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007254 (JNK cascade)
GO:0009615 (response to virus)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0016032 (viral process)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0051650 (establishment of vesicle localization)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:1901215 (negative regulation of neuron death)
Wikipedia IKBKG

Target Cross References - Protein

canSAR Q9Y6K9
CGD Invasive pneumococcal disease, recurrent, isolated, 2; Atypical mycobacteriosis, familial, X-linked, 1; Immunodeficiency, isolated
Human Protein Atlas ENSG00000269335
IntAct Q9Y6K9
Open Targets ENSG00000269335
PharmGKB PA29777
Pharos Q9Y6K9 (Tbio)
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5602636 (IKBKB deficiency causes SCID.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5684264 (MAP3K8 (TPL2)-dependent MAPK1/3 activation.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-5689896 (Ovarian tumor domain proteases.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
R-HSA-933543 (NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10.)
R-HSA-937039 (IRAK1 recruits IKK complex.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
R-HSA-975144 (IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.)
UniProt Q7LBY6 Q7Z7F1 Q9Y6K9

Target Cross References - Domain

InterPro IPR021063 (NEMO_N.)
IPR032419 (CC2-LZ_dom.)
Pfam PF11577 (NEMO)
PF16516 (CC2-LZ)

Target Cross References - Structure

PDBe 3BRT 3BRV 3CL3 3FX0 4BWN
CREDO 3BRT 3BRV 3CL3 3FX0 4BWN
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