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Target Report Card

Target Name and Classification

Target ID CHEMBL4958
Target Type SINGLE PROTEIN
Preferred Name Dynamin-1
Synonyms DNM | DNM1 | Dynamin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • structural protein
  • enzyme

Target Components

Component Description Relationship Accession
Dynamin-1 SINGLE PROTEIN Q05193

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106976
Ensembl ENSG00000106976
GO Cellular Component GO:0001917 (photoreceptor inner segment)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0030117 (membrane coat)
GO:0043196 (varicosity)
GO:0043209 (myelin sheath)
GO:0043234 (protein complex)
GO:0045202 (synapse)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0008022 (protein C-terminus binding)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO:0031749 (D2 dopamine receptor binding)
GO:0032403 (protein complex binding)
GO:0042802 (identical protein binding)
GO:0044822 (poly(A) RNA binding)
GO:0046983 (protein dimerization activity)
GO:0050998 (nitric-oxide synthase binding)
GO Biological Process GO:0002031 (G-protein coupled receptor internalization)
GO:0006897 (endocytosis)
GO:0006898 (receptor-mediated endocytosis)
GO:0007032 (endosome organization)
GO:0007605 (sensory perception of sound)
GO:0008344 (adult locomotory behavior)
GO:0031623 (receptor internalization)
GO:0048013 (ephrin receptor signaling pathway)
GO:0051262 (protein tetramerization)
GO:0051932 (synaptic transmission, GABAergic)
GO:0072583 (clathrin-mediated endocytosis)
GO:1901998 (toxin transport)
GO:1903423 (positive regulation of synaptic vesicle recycling)
Wikipedia DNM1

Target Cross References - Protein

canSAR Q05193
Human Protein Atlas ENSG00000106976
IntAct Q05193
Open Targets ENSG00000106976
PharmGKB PA27440
Reactome R-HSA-166016 (Toll Like Receptor 4 (TLR4) Cascade.)
R-HSA-177504 (Retrograde neurotrophin signalling.)
R-HSA-190873 (Gap junction degradation.)
R-HSA-196025 (Formation of annular gap junctions.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt A6NLM6 Q05193 Q5SYX0 Q5SYX2 Q6P3T6 Q86VD2

Target Cross References - Domain

InterPro IPR000375 (Dynamin_central.)
IPR001401 (Dynamin_GTPase.)
IPR001849 (PH_domain.)
IPR003130 (GED.)
IPR011993 (PH_dom-like.)
IPR019762 (Dynamin_GTPase_CS.)
IPR020850 (GED_dom.)
IPR022812 (Dynamin_SF.)
IPR027417 (P-loop_NTPase.)
IPR027741 (DNM1.)
IPR030381 (G_DYNAMIN_dom.)
Pfam PF00169 (PH)
PF00350 (Dynamin_N)
PF01031 (Dynamin_M)
PF02212 (GED)

Target Cross References - Structure

PDBe 1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 5D3Q
CREDO 1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 5D3Q
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