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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4958
Target Type SINGLE PROTEIN
Preferred Name Dynamin-1
Synonyms DNM | DNM1 | Dynamin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • structural protein
  • enzyme

Target Components

Component Description Relationship Accession
Dynamin-1 SINGLE PROTEIN Q05193

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106976
Ensembl ENSG00000106976
GO Cellular Component GO:0005874 (microtubule)
GO:0043209 (myelin sheath)
GO:0030117 (membrane coat)
GO:0070062 (extracellular exosome)
GO:0001917 (photoreceptor inner segment)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0003924 (GTPase activity)
GO:0005525 (GTP binding)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0051932 (synaptic transmission, GABAergic)
GO:1901998 (toxin transport)
GO:0051262 (protein tetramerization)
GO:0007032 (endosome organization)
GO:0007411 (axon guidance)
GO:0048013 (ephrin receptor signaling pathway)
GO:0072583 (clathrin-mediated endocytosis)
GO:0006898 (receptor-mediated endocytosis)
GO:0007605 (sensory perception of sound)
GO:0008344 (adult locomotory behavior)
GO:0006897 (endocytosis)
Wikipedia DNM1

Target Cross References - Protein

canSAR Q05193
Human Protein Atlas ENSG00000106976
IntAct Q05193
PharmGKB PA27440
UniProt Q6P3T6 A6NLM6 Q5SYX2 Q05193 Q86VD2 Q5SYX0

Target Cross References - Domain

InterPro IPR001849 (PH_domain.)
IPR011993 (PH/PTB_dom.)
IPR003130 (GED.)
IPR027741 (DNM1.)
IPR030381 (G_DYNAMIN_dom.)
IPR027417 (P-loop_NTPase.)
IPR000375 (Dynamin_central.)
IPR001401 (Dynamin_GTPase.)
IPR019762 (Dynamin_GTPase_CS.)
IPR020850 (GED_dom.)
IPR022812 (Dynamin_SF.)
Pfam PF00169 (PH)
PF00350 (Dynamin_N)
PF02212 (GED)
PF01031 (Dynamin_M)

Target Cross References - Structure

PDBe 3ZYC 3SNH 2X2E 2X2F 1DYN 2DYN
CREDO 3ZYC 3SNH 2X2E 2X2F 1DYN 2DYN
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