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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4954
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 3
Synonyms EK4 | EPH-like kinase 4 | EPHA3 | ETK | ETK1 | Eph-like tyrosine kinase 1 | Ephrin type-A receptor 3 | HEK | HEK | Human embryo kinase | TYRO4 | Tyrosine-protein kinase TYRO4 | Tyrosine-protein kinase receptor ETK1 | hEK4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 3 SINGLE PROTEIN P29320

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000044524
Ensembl ENSG00000044524
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005769 (early endosome)
GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0005524 (ATP binding)
GO:0005004 (GPI-linked ephrin receptor activity)
GO Biological Process GO:0032956 (regulation of actin cytoskeleton organization)
GO:0097156 (fasciculation of motor neuron axon)
GO:0070507 (regulation of microtubule cytoskeleton organization)
GO:0007411 (axon guidance)
GO:0010717 (regulation of epithelial to mesenchymal transition)
GO:0048013 (ephrin receptor signaling pathway)
GO:0071300 (cellular response to retinoic acid)
GO:0043087 (regulation of GTPase activity)
GO:0051893 (regulation of focal adhesion assembly)
GO:0097155 (fasciculation of sensory neuron axon)
GO:0007155 (cell adhesion)
GO:0010976 (positive regulation of neuron projection development)
GO:0016477 (cell migration)
Wikipedia EPH_receptor_A3

Target Cross References - Protein

canSAR P29320
Human Protein Atlas ENSG00000044524
IntAct P29320
Guide to Pharmacology 1823 (EPH receptor A3)
PharmGKB PA27819
UniProt P29320 Q9H2V4 Q9H2V3

Target Cross References - Domain

InterPro IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR009030 (Growth_fac_rcpt_N_dom.)
IPR027936 (Eph_TM.)
IPR003961 (FN3_dom.)
IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR008979 (Galactose-bd-like.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
Pfam PF00041 (fn3)
PF07647 (SAM_2)
PF07699 (GCC2_GCC3)
PF14575 (EphA2_TM)
PF07714 (Pkinase_Tyr)
PF01404 (Ephrin_lbd)

Target Cross References - Structure

PDBe 2QO9 3DZQ 4P5Z 2QOC 2QOL 3FXX 4GK4 2QOF 2QOO 3FY2 4P5Q 2QO2 2QOD 2QOI 2QOQ 4G2F 2QOB 2QOK 2QON 4P4C 4TWN 4TWO 2QO7 4GK2 More...
CREDO 2QO9 3DZQ 4P5Z 2QOC 2QOL 3FXX 4GK4 2QOF 2QOO 3FY2 4P5Q 2QO2 2QOD 2QOI 2QOQ 4G2F 2QOB 2QOK 2QON 4P4C 4TWN 4TWO 2QO7 4GK2 More...
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