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Target Report Card

Target Name and Classification

Target ID CHEMBL4948
Target Type SINGLE PROTEIN
Preferred Name Dual specificity mitogen-activated protein kinase kinase 5
Synonyms Dual specificity mitogen-activated protein kinase kinase 5 | MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK 5 | MEK5 | MKK5 | PRKMK5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 5 SINGLE PROTEIN Q13163

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137764
Ensembl ENSG00000137764
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007507 (heart development)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030307 (positive regulation of cell growth)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0034115 (negative regulation of heterotypic cell-cell adhesion)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045415 (negative regulation of interleukin-8 biosynthetic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051247 (positive regulation of protein metabolic process)
GO:0060761 (negative regulation of response to cytokine stimulus)
GO:0070375 (ERK5 cascade)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071499 (cellular response to laminar fluid shear stress)
GO:0090051 (negative regulation of cell migration involved in sprouting angiogenesis)
GO:2000342 (negative regulation of chemokine (C-X-C motif) ligand 2 production)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia MAP2K5

Target Cross References - Protein

canSAR Q13163
Human Protein Atlas ENSG00000137764
IntAct Q13163
Guide to Pharmacology 2066
Open Targets ENSG00000137764
PharmGKB PA30590
Pharos Q13163 (Tchem)
Reactome R-HSA-198765 (Signalling to ERK5.)
UniProt B4DE43 Q13163 Q92961 Q92962

Target Cross References - Domain

InterPro IPR000270 (PB1_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00564 (PB1)

Target Cross References - Structure

PDBe 2NPT 2O2V 4IC7
CREDO 2NPT 2O2V 4IC7
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