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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4934
Target Type SINGLE PROTEIN
Preferred Name Spermine synthase
Synonyms SMS | SPMSY | Spermidine aminopropyltransferase | Spermine synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Spermine synthase SINGLE PROTEIN P52788

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102172
Ensembl ENSG00000102172
GO Cellular Component GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0016740 (transferase activity)
GO:0016768 (spermine synthase activity)
GO Biological Process GO:0006555 (methionine metabolic process)
GO:0006595 (polyamine metabolic process)
GO:0006596 (polyamine biosynthetic process)
GO:0006597 (spermine biosynthetic process)
GO:0008215 (spermine metabolic process)
Wikipedia SMS_(gene)

Target Cross References - Protein

canSAR P52788
CGD Mental retardation, X-linked, Snyder-Robinson type
Human Protein Atlas ENSG00000102172
IntAct P52788
Open Targets ENSG00000102172
PharmGKB PA35972
Reactome R-HSA-351202 (Metabolism of polyamines.)
UniProt A6NHA7 A6NI34 B2R9M0 O00544 P52788 Q9UQS1

Target Cross References - Domain

InterPro IPR015576 (Spermine_synthase_animal.)
IPR029063 (SAM-dependent_MTases.)
IPR030373 (PABS_CS.)
IPR030374 (PABS.)

Target Cross References - Structure

PDBe 3C6K 3C6M
CREDO 3C6K 3C6M
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