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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4933
Target Type SINGLE PROTEIN
Preferred Name Glutathione S-transferase A4
Synonyms GST class-alpha member 4 | GSTA4 | Glutathione S-transferase A4 | Glutathione S-transferase A4-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase A4 SINGLE PROTEIN O15217

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170899
Ensembl ENSG00000170899
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008152 (metabolic process)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia GSTA4

Target Cross References - Protein

canSAR O15217
Human Protein Atlas ENSG00000170899
IntAct O15217
Open Targets ENSG00000170899
PharmGKB PA29019
Reactome R-HSA-156590 (Glutathione conjugation.)
UniProt B2RD15 O15217 Q5T7Q8 Q6P4G1 Q9BX18 Q9H414

Target Cross References - Domain

InterPro IPR003080 (GST_alpha.)
IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR012336 (Thioredoxin-like_fold.)
Pfam PF02798 (GST_N)
PF14497 (GST_C_3)

Target Cross References - Structure

PDBe 1GUL 1GUM 3IK7
CREDO 1GUL 1GUM 3IK7
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