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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4929
Target Type SINGLE PROTEIN
Preferred Name Serum amyloid P-component
Synonyms 9.5S alpha-1-glycoprotein | APCS | PTX2 | SAP | Serum amyloid P-component | Serum amyloid P-component(1-203)
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Serum amyloid P-component SINGLE PROTEIN P02743

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132703
Ensembl ENSG00000132703
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0001849 (complement component C1q binding)
GO:0005509 (calcium ion binding)
GO:0030246 (carbohydrate binding)
GO:0046790 (virion binding)
GO:0046872 (metal ion binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0002674 (negative regulation of acute inflammatory response)
GO:0006457 (protein folding)
GO:0006953 (acute-phase response)
GO:0044267 (cellular protein metabolic process)
GO:0044869 (negative regulation by host of viral exo-alpha-sialidase activity)
GO:0044871 (negative regulation by host of viral glycoprotein metabolic process)
GO:0045087 (innate immune response)
GO:0045656 (negative regulation of monocyte differentiation)
GO:0046597 (negative regulation of viral entry into host cell)
GO:0048525 (negative regulation of viral process)
GO:0051131 (chaperone-mediated protein complex assembly)
GO:0061045 (negative regulation of wound healing)
GO:1903016 (negative regulation of exo-alpha-sialidase activity)
GO:1903019 (negative regulation of glycoprotein metabolic process)
Wikipedia Serum_amyloid_P_component

Target Cross References - Protein

canSAR P02743
Human Protein Atlas ENSG00000132703
IntAct P02743
Guide to Pharmacology 2839
Open Targets ENSG00000132703
PharmGKB PA24877
Reactome R-HSA-977225 (Amyloid fiber formation.)
UniProt P02743

Target Cross References - Domain

InterPro IPR001759 (Pentraxin-related.)
IPR013320 (ConA-like_dom.)
IPR030476 (Pentaxin_CS.)
Pfam PF00354 (Pentaxin)

Target Cross References - Structure

PDBe 1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
CREDO 1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
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