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Target Report Card

Target Name and Classification

Target ID CHEMBL4917
Preferred Name Complement C3
Synonyms ASP | Acylation stimulating protein | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 | C3 | C3-beta-c | C3a anaphylatoxin | C3adesArg | C3bc | CPAMD1 | Complement C3 alpha chain | Complement C3 beta chain | Complement C3 | Complement C3b alpha' chain | Complement C3c alpha' chain fragment 1 | Complement C3c alpha' chain fragment 2 | Complement C3d fragment | Complement C3dg fragment | Complement C3f fragment | Complement C3g fragment
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Complement C3 SINGLE PROTEIN P01024

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125730
Ensembl ENSG00000125730
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0004866 (endopeptidase inhibitor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008289 (lipid binding)
GO:0031715 (C5L2 anaphylatoxin chemotactic receptor binding)
GO:0048037 (cofactor binding)
GO Biological Process GO:0001798 (positive regulation of type IIa hypersensitivity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001970 (positive regulation of activation of membrane attack complex)
GO:0002376 (immune system process)
GO:0002507 (tolerance induction)
GO:0006508 (proteolysis)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006956 (complement activation)
GO:0006957 (complement activation, alternative pathway)
GO:0006958 (complement activation, classical pathway)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007596 (blood coagulation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010828 (positive regulation of glucose transport)
GO:0010866 (regulation of triglyceride biosynthetic process)
GO:0010884 (positive regulation of lipid storage)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0030449 (regulation of complement activation)
GO:0032026 (response to magnesium ion)
GO:0032355 (response to estradiol)
GO:0032570 (response to progesterone)
GO:0043627 (response to estrogen)
GO:0045087 (innate immune response)
GO:0045745 (positive regulation of G-protein coupled receptor protein signaling pathway)
GO:0045766 (positive regulation of angiogenesis)
GO:0048639 (positive regulation of developmental growth)
GO:0050766 (positive regulation of phagocytosis)
GO:0050776 (regulation of immune response)
GO:0051384 (response to glucocorticoid)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:2000427 (positive regulation of apoptotic cell clearance)
Wikipedia Complement_component_3

Target Cross References - Protein

canSAR P01024
CGD Complement component 3 deficiency, autosomal recessive; Hemolytic uremic syndrome, atypical, susceptibility to, 5
Human Protein Atlas ENSG00000125730
IntAct P01024
Open Targets ENSG00000125730
PharmGKB PA25897
Reactome R-HSA-173736 (Alternative complement activation.)
R-HSA-174577 (Activation of C3 and C5.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt A7E236 P01024

Target Cross References - Domain

InterPro IPR000020 (Anaphylatoxin/fibulin.)
IPR001134 (Netrin_domain.)
IPR001599 (Macroglobln_a2.)
IPR001840 (Anaphylatoxn_comp_syst_dom.)
IPR002890 (A2M_N.)
IPR008930 (Terpenoid_cyclase/PrenylTrfase.)
IPR008993 (TIMP-like_OB-fold.)
IPR009048 (A-macroglobulin_rcpt-bd.)
IPR011625 (A2M_N_2.)
IPR011626 (A2M_comp.)
IPR018081 (Anaphylatoxin_comp_syst.)
IPR018933 (Netrin_module_non-TIMP.)
IPR019565 (MacrogloblnA2_thiol-ester-bond.)
IPR019742 (MacrogloblnA2_CS.)
Pfam PF00207 (A2M)
PF01759 (NTR)
PF01821 (ANATO)
PF01835 (A2M_N)
PF07677 (A2M_recep)
PF07678 (A2M_comp)
PF07703 (A2M_N_2)
PF10569 (Thiol-ester_cl)

Target Cross References - Structure

PDBe 1C3D 1GHQ 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED More...
CREDO 1C3D 1GHQ 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED More...