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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4905
Target Type SINGLE PROTEIN
Preferred Name Receptor-type tyrosine-protein phosphatase gamma
Synonyms PTPG | PTPRG | Protein-tyrosine phosphatase gamma | R-PTP-gamma | Receptor-type tyrosine-protein phosphatase gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase > receptor tyrosine-protein phosphatase

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein phosphatase gamma SINGLE PROTEIN P23470

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144724
Ensembl ENSG00000144724
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005887 (integral to plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004725 (protein tyrosine phosphatase activity)
GO:0005001 (transmembrane receptor protein tyrosine phosphatase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0010633 (negative regulation of epithelial cell migration)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:1901998 (toxin transport)
Wikipedia PTPRG

Target Cross References - Protein

canSAR P23470
Human Protein Atlas ENSG00000144724
IntAct P23470
PharmGKB PA34016
UniProt B2RU12 P23470 Q15623 Q59EE0 Q68DU5

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000242 (Tyr_Pase_rcpt/non-rcpt.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR000387 (Tyr/Dual-specificity_Pase.)
IPR001148 (Carbonic_anhydrase_a-class_cat.)
IPR001148 (Carbonic_anhydrase_a.)
IPR003961 (FN3_dom.)
IPR003961 (FN_III.)
IPR008957 (Fibronectin_III_dom.)
IPR013783 (Ig-like_fold.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00041 (fn3)
PF00102 (Y_phosphatase)
PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN
CREDO 2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN
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