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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4901
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-B receptor 3
Synonyms EK2 | EPH-like kinase 2 | EPH-like tyrosine kinase 2 | EPHB3 | ETK2 | Embryonic kinase 2 | Ephrin type-B receptor 3 | HEK2 | TYRO6 | Tyrosine-protein kinase TYRO6 | hEK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 3 SINGLE PROTEIN P54753

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182580
Ensembl ENSG00000182580
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005003 (ephrin receptor activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
Wikipedia EPHB3

Target Cross References - Protein

canSAR P54753
Human Protein Atlas ENSG00000182580
Guide to Pharmacology 1832 (EPH receptor B3)
PharmGKB PA27826
UniProt P54753 Q7Z740

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001090 (Ephrin_rcpt_lig-bd.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001426 (Tyr_prot_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN_III.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR008957 (Fibronectin_III_dom.)
IPR008979 (Galactose-bd-like.)
IPR010993 (Sterile_alpha_motif_homology.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM_type.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_prot_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR021129 (SAM_type1.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07699 (GCC2_GCC3)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3P1I
CREDO 3P1I
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