ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4900
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase D2
Synonyms PKD2 | PRKD2 | Serine/threonine-protein kinase D2 | nPKC-D2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase pkd family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase D2 SINGLE PROTEIN Q9BZL6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105287
Ensembl ENSG00000105287
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0008219 (cell death)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038033 (positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045743 (positive regulation of fibroblast growth factor receptor signaling pathway)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050852 (T cell receptor signaling pathway)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0061154 (endothelial tube morphogenesis)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0089700 (protein kinase D signaling)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:1901727 (positive regulation of histone deacetylase activity)
GO:1902533 (positive regulation of intracellular signal transduction)
GO:2000573 (positive regulation of DNA biosynthetic process)
GO:2001028 (positive regulation of endothelial cell chemotaxis)
Wikipedia PRKD2

Target Cross References - Protein

Human Protein Atlas ENSG00000105287
IntAct Q9BZL6
Guide to Pharmacology 2173
Open Targets ENSG00000105287
PharmGKB PA134903505
Pharos Q9BZL6 (Tchem)
Reactome R-HSA-1660661 (Sphingolipid de novo biosynthesis.)
UniProt M0R2R2 Q8NCK8 Q8TB08 Q9BZL6 Q9P0T6 Q9Y3X8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR015727 (Protein_Kinase_C_mu-related.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)

Target Cross References - Structure

PDBe 3BGM 4NNX 4NNY
CREDO 3BGM 4NNX 4NNY
spacer
spacer