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Target Report Card

Target Name and Classification

Target ID CHEMBL4899
Preferred Name Mitogen-activated protein kinase kinase kinase 8
Synonyms COT | Cancer Osaka thyroid oncogene | ESTF | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Proto-oncogene c-Cot | Serine/threonine-protein kinase cot | TPL-2 | Tumor progression locus 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 8 SINGLE PROTEIN P41279

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107968
Ensembl ENSG00000107968
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0031295 (T cell costimulation)
GO:0051403 (stress-activated MAPK cascade)
Wikipedia MAP3K8

Target Cross References - Protein

canSAR P41279
Human Protein Atlas ENSG00000107968
IntAct P41279
Guide to Pharmacology 2083
Open Targets ENSG00000107968
PharmGKB PA30606
Pharos P41279 (Tchem)
Reactome R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-5684264 (MAP3K8 (TPL2)-dependent MAPK1/3 activation.)
UniProt A8K2Q5 D3DRX1 P41279 Q14275 Q5T855 Q9HC81

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017424 (MAPKKK8.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4Y83 4Y85 5IU2
CREDO 4Y83 4Y85 5IU2