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Target Report Card

Target Name and Classification

Target ID CHEMBL4898
Target Type SINGLE PROTEIN
Preferred Name Neurotrophic tyrosine kinase receptor type 2
Synonyms BDNF/NT-3 growth factors receptor | GP145-TrkB | NTRK2 | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
BDNF/NT-3 growth factors receptor SINGLE PROTEIN Q16620

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559684 Neurotrophic tyrosine kinase receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL603469 LESTAURTINIB Neurotrophic tyrosine kinase receptor type 2 inhibitor 3 PubMed
CHEMBL3545179 AZD-7451 Neurotrophic tyrosine kinase receptor type 2 inhibitor 1 PubMed PubMed
CHEMBL3545381 PLX-7486 Neurotrophic tyrosine kinase receptor type 2 inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148053
Ensembl ENSG00000148053
GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0010008 (endosome membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031901 (early endosome membrane)
GO:0043195 (terminal bouton)
GO:0043235 (receptor complex)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0043121 (neurotrophin binding)
GO:0048403 (brain-derived neurotrophic factor binding)
GO:0060175 (brain-derived neurotrophic factor-activated receptor activity)
GO Biological Process GO:0001570 (vasculogenesis)
GO:0001764 (neuron migration)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007528 (neuromuscular junction development)
GO:0007612 (learning)
GO:0007623 (circadian rhythm)
GO:0007631 (feeding behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0010976 (positive regulation of neuron projection development)
GO:0014047 (glutamate secretion)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019222 (regulation of metabolic process)
GO:0021954 (central nervous system neuron development)
GO:0021987 (cerebral cortex development)
GO:0030154 (cell differentiation)
GO:0030182 (neuron differentiation)
GO:0031547 (brain-derived neurotrophic factor receptor signaling pathway)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0038179 (neurotrophin signaling pathway)
GO:0042490 (mechanoreceptor differentiation)
GO:0043087 (regulation of GTPase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0046548 (retinal rod cell development)
GO:0046777 (protein autophosphorylation)
GO:0048709 (oligodendrocyte differentiation)
GO:0048935 (peripheral nervous system neuron development)
GO:0050772 (positive regulation of axonogenesis)
GO:0051896 (regulation of protein kinase B signaling)
GO:0051965 (positive regulation of synapse assembly)
GO:0060041 (retina development in camera-type eye)
GO:0060291 (long-term synaptic potentiation)
GO:0071230 (cellular response to amino acid stimulus)
GO:0099551 (trans-synaptic signaling by neuropeptide, modulating synaptic transmission)
GO:2000811 (negative regulation of anoikis)
Wikipedia TrkB_receptor

Target Cross References - Protein

canSAR Q16620
CGD Obesity, hyperphagia, and developmental delay
Human Protein Atlas ENSG00000148053
IntAct Q16620
Guide to Pharmacology 1818
Open Targets ENSG00000148053
PharmGKB PA31818
Pharos Q16620 (Tchem)
Reactome R-HSA-187024 (NGF-independant TRKA activation.)
UniProt B1ANZ4 B4DFV9 Q16620 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7

Target Cross References - Domain

InterPro IPR000372 (LRRNT.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020455 (Tyr_kin_neurotrophic_rcpt_2.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020777 (Tyr_kinase_NGF_rcpt.)
IPR031635 (NTRK_C2.)
IPR032675 (LRR_dom_sf.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF01462 (LRRNT)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)
PF13855 (LRR_8)
PF16920 (TPKR_C2)

Target Cross References - Structure

PDBe 1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5 5MO9
CREDO 1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5 5MO9
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