ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4898
Preferred Name Neurotrophic tyrosine kinase receptor type 2
Synonyms BDNF/NT-3 growth factors receptor | GP145-TrkB | NTRK2 | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
BDNF/NT-3 growth factors receptor SINGLE PROTEIN Q16620

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559684 Neurotrophic tyrosine kinase receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL603469 LESTAURTINIB Neurotrophic tyrosine kinase receptor type 2 inhibitor 3 PubMed
CHEMBL3545179 AZD-7451 Neurotrophic tyrosine kinase receptor type 2 inhibitor 1 PubMed PubMed
CHEMBL3545381 PLX-7486 Neurotrophic tyrosine kinase receptor type 2 inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148053
Ensembl ENSG00000148053
GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005791 (rough endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043204 (perikaryon)
GO:0043235 (receptor complex)
GO:0043679 (axon terminus)
GO:0045211 (postsynaptic membrane)
GO:0048786 (presynaptic active zone)
GO:0060076 (excitatory synapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030971 (receptor tyrosine kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0043121 (neurotrophin binding)
GO:0048403 (brain-derived neurotrophic factor binding)
GO:0060175 (brain-derived neurotrophic factor-activated receptor activity)
GO Biological Process GO:0001570 (vasculogenesis)
GO:0001764 (neuron migration)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007528 (neuromuscular junction development)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007616 (long-term memory)
GO:0007623 (circadian rhythm)
GO:0007631 (feeding behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0009416 (response to light stimulus)
GO:0010628 (positive regulation of gene expression)
GO:0010976 (positive regulation of neuron projection development)
GO:0010996 (response to auditory stimulus)
GO:0014047 (glutamate secretion)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019222 (regulation of metabolic process)
GO:0021954 (central nervous system neuron development)
GO:0021987 (cerebral cortex development)
GO:0030154 (cell differentiation)
GO:0030182 (neuron differentiation)
GO:0031547 (brain-derived neurotrophic factor receptor signaling pathway)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0038179 (neurotrophin signaling pathway)
GO:0042490 (mechanoreceptor differentiation)
GO:0043087 (regulation of GTPase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0046548 (retinal rod cell development)
GO:0046777 (protein autophosphorylation)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048709 (oligodendrocyte differentiation)
GO:0048935 (peripheral nervous system neuron development)
GO:0050772 (positive regulation of axonogenesis)
GO:0050773 (regulation of dendrite development)
GO:0051896 (regulation of protein kinase B signaling)
GO:0051965 (positive regulation of synapse assembly)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060041 (retina development in camera-type eye)
GO:0060291 (long-term synaptic potentiation)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071356 (cellular response to tumor necrosis factor)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus)
GO:2000811 (negative regulation of anoikis)
Wikipedia TrkB_receptor

Target Cross References - Protein

canSAR Q16620
CGD Obesity, hyperphagia, and developmental delay
Human Protein Atlas ENSG00000148053
IntAct Q16620
Guide to Pharmacology 1818
Open Targets ENSG00000148053
PharmGKB PA31818
Pharos Q16620 (Tchem)
Reactome R-HSA-187024 (NGF-independant TRKA activation.)
UniProt B1ANZ4 B4DFV9 Q16620 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7

Target Cross References - Domain

InterPro IPR000372 (LRRNT.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020455 (Tyr_kin_neurotrophic_rcpt_2.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020777 (Tyr_kinase_NGF_rcpt.)
IPR031635 (NTRK_C2.)
IPR032675 (L_dom-like.)
Pfam PF01462 (LRRNT)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)
PF13855 (LRR_8)
PF16920 (TPKR_C2)

Target Cross References - Structure